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Recombinant Human Sushi domain-containing protein 2 (SUSD2), partial

Recombinant Human Sushi domain-containing protein 2 (SUSD2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

SUSD2

Purity

>85% (SDS-PAGE)

Target Names

SUSD2

Uniprot NO.

Q9UGT4

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.

Gene References into Functions

platelet activation and binding to high-grade serous ovarian carcinoma cells was inversely correlated with the presence of SUSD2. This represents one of the first tumor proteins known to provide differential platelet interaction based on protein status. PMID:30335544
suggest that SUSD2 counteracts senescence and cell death and is thus a potential chemotherapeutic target in human endometrial cancer PMID:28841682
Tumors with high levels of SUSD2 staining contained 2-fold more tumor-associated macrophages, mainly of the M2 pro-angiogenic phenotype PMID:28475599
Low SUSD2 expression is associated with renal cell carcinoma and lung cancer. PMID:26815503
No evidence of association between polymorphisms in SUSD2 and sporadic amyotrophic lateral sclerosis in Han Chinese PMID:25677198
Authors found significantly fewer CD4 tumor infiltrating lymphocytes in breast tumors expressing Susd2. PMID:23131994
Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1. PMID:23624525

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus. Also expressed in colon; down-regulated in colon cancer tis

Database Links

HGNC: 30667

UNIGENE: Hs.131819

KEGG: hsa:56241

STRING: 9606.ENSP00000351075

OMIM: 615825

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