Recombinant Human Structural maintenance of chromosomes protein 3 (SMC3), partial

1. H2 inhibited lung cancer progression through down-regulating SMC3. PMID:29852353
2. We identified a large number of mutations in the CC region of both Smc1 and Smc3... we introduced them to the yeast Smc1 and Smc3 CC domains and characterized the effect of these mutant alleles on cohesin's function. We identified a missense mutation in the region of the kink domain of Smc3, which was previously identified in kidney carcinoma PMID:27307603
3. Results show that SMC3 is upregulated in asthma patients and suggest that it may play an important role in atopic asthma development, especially in asthma epithelial-mesenchymal transition. PMID:25515564
4. Data show that histone deacetylase 8 (HDAC8) inhibition led to accumulation of acetylated-SMC3 protein but had no influence on the transcription of estrogen-responsive genes. PMID:27072133
5. De novo heterozygous mutations in SMC3 cause a range of Cornelia de Lange syndrome-overlapping phenotypes PMID:25655089
6. cohesin's proposed DNA exit gate is formed by interactions between Scc1 and the coiled-coil region of Smc3. PMID:25414306
7. Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2, SMC3, and RAD21 mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation PMID:25006131
8. Mutations in SMC3 is associated with acute myeloid leukemia. PMID:24335498
9. Upon knock-down of human SMC1, much of SMC3 remains stable, accumulates in the cytoplasm and does not associate with other cohesin proteins. PMID:23776448
10. SMC3 and separase are upregulated and securin is downregulated in malignant transformation of BEAS-2B cells induced by coal tar pitch smoke extracts. PMID:21126432
11. these studies clearly suggest that bamacan interacts with the vaccinia virus-N1L and such interactions seem to play a positive role in promoting the viral growth and perhaps contribute to the virulence of VV in neural cells. PMID:19444697
12. identification as target for beta-catenin/T-cell factor 4 transactivation pathway PMID:12651860
13. Hinderin is a novel binding partner of SMC3. Based on its ability to modulate SMC1/SMC3 interaction we postulate that Hinderin affects the availability of SMC3 to engage in the formation of multimeric protein complexes PMID:15656913
14. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC3. PMID:16043481
15. RhoB and cAMP cis-acting response elements -BPa two known oncogenic mediators whose expression is significantly increased following SMC3 overexpression play a significant role in mediating SMC3 tumorigenesis PMID:16156898
16. SMC3 deficiency affects chromosomal stability leading to the activation of p53-dependent mitotic checkpoint. PMID:17081288
17. Mutations in SMC3 cause a mild variant of cornelia de Lange syndrome with predominant mental retardation PMID:17273969
18. phosphorylation of a core cohesin subunit SMC3 by ATM plays an important role in DNA damage PMID:18442975
19. This study identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion. PMID:18614053
20. There were greater levels of chondroitin sulphate WF6 epitope in gingival crevicular fluid from destructive sites of patients with chronic periodontitis compared with non-destructive sites of patients with gingivitis or chronic periodontitis. PMID:18727658
21. Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue, and show intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients. PMID:19094982

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HGNC: 2468

UNIGENE: Hs.24485

KEGG: hsa:9126

STRING: 9606.ENSP00000354720

OMIM: 606062