Recombinant Human Selenium-binding protein 1 (SELENBP1)

1. High anti-SBP1 is associated with infertile women with premature ovarian failure. PMID:27965399
2. Downregulation of selenium-binding protein 1 is associated with lung squamous cell carcinoma. PMID:26956891
3. cysteine 57 is a critical determinant of SBP1 function and may play a significant role in mitochondrial function. PMID:26593911
4. Data indicate that loss of SBP1 may play an independent contributing role in prostate cancer progression and its levels might be useful in distinguishing indolent from aggressive disease. PMID:25993660
5. elevated transcript expression is widespread throughout the prefrontal cortex in schizophrenia PMID:26241353
6. These results have revealed a novel mechanism that SELENBP1-mediated cancer inhibition is through altering lipid/glucose metabolic signaling pathways. PMID:25974208
7. Decreased selenium-binding protein 1 mRNA expression is associated with renal cell carcinoma. PMID:25227434
8. hSP56 plays an important role in regulating HIF-1alpha, which may be one of mechanisms of hSP56 expression in suppressing the malignant characteristics of prostate cancer cells. PMID:24874852
9. the downregulated SELENBP1 expression was reactivated by inducing differentiation. Therefore, SELENBP1 is a potential pharmacological target for individualized CRC treatment. PMID:24737289
10. Decreased SELENBP1 expression is an early event in lung squamous cell cancer tumorigenesis. PMID:23977169
11. The expression level of SELENBP1 could be an important marker for predicting survival and effectiveness of selenium supplementation in breast cancer. PMID:23704933
12. These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs PMID:23483240
13. SP1 is present in reduced levels in several cancer types as compared with normal tissues, and lower levels are associated with poor clinical prognosis. PMID:20530237
14. Glutathione peroxidase (GPx)-1 enzyme activity is inversely correlated with selenium binding protein (SBP)-1 levels in prostate tissue, based on the Gleason score. PMID:22072582
15. The suppression of Selenium-binding protein 1 may be a late event in gastric carcinogenesis. PMID:20480265
16. The 3-year survival rate of gastric cancer patients with high expression of selenium-binding protein 1 was significantly higher than that of patients with low expression PMID:21497372
17. down-regulation of SBP1 may play a key role in the tumorigenic process of human gastric carcinoma PMID:20354826
18. Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis. PMID:21143902
19. A reduced SELENBP1 expression by immunohistochemistry in liver tissues of patients with hepatocarcinoma (HCC), is reported. PMID:21338716
20. evidence for recurrence of decreased copy-number of the SELENBP1 locus in three unrelated schizophrenia patients' cohorts but not in controls, raising the possibility of functional involvement of these mutations in the etiology of the disease PMID:20615253
21. SELENBP1 expression may be an important predictor of response to chemoprevention or chemosensitization with certain forms of selenium in esophageal tissues. PMID:20332323
22. SBP1 has tumor suppressor functions that are inhibited in colorectal cancer through epigenetic silencing PMID:19924303
23. loss of selenium-binding protein 1 associated with increasing epithelial proliferation indicates selenium-binding protein 1 is involved in tumorigenesis of ovarian and micropapillary serous borderline tumor and low-grade serous carcinoma. PMID:19896693
24. SBP may be involved in the initial sequential events in rapid cell outgrowth, such as determining direction of cell outgrowth and recruitment of actin monomer. PMID:15108003
25. changes of SELENBP1 expression in malignant ovarian cancer are an indicator of aberration of selenium/androgen pathways and may reveal prognostic information of ovarian cancer PMID:16380993
26. Suppression of SELENBP1 is a frequent and late event in colorectal carcinogenesis, and may contribute to the rapid progression of colorectal carcinoma. PMID:16645984
27. Elevated SELENBP1 is a possibly consistent feature in the schizophrenic brain and this could underlie some commonalities of psychosis across the boundaries of diagnoses. PMID:18163446
28. Associated with differentiation of the normal colonic epithelia and may be a positive prognostic factor for survival in stage III colorectal carcinoma PMID:18435490
29. VDU1 was identified as a protein partner of hSP56. PMID:19118533
30. The genetic variation in SELENBP1 may influence risk for the disorder, while this significance did not remain when other inheritance models were considered. PMID:19596560

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HGNC: 10719

UNIGENE: Hs.632460

KEGG: hsa:8991

STRING: 9606.ENSP00000357861

OMIM: 604188