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Recombinant Human SARS coronavirus Protein 9b (9b)

Recombinant Human SARS coronavirus Protein 9b (9b)

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

P59636

Species

Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)

Source

Yeast

Expression Region

1-98

Target Protein Sequence

MDPNQTNVVP PALHLVDPQI QLTITRMEDA MGQGQNSADP KVYPIILRLG SQLSLSMARR NLDSLEARAF QSTPIVVQMT KLATTEELPD EFVVVTAK

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.

Gene References into Functions

SARS-CoV ORF-9b manipulates host cell mitochondria and mitochondrial function to help evade host innate immunity. PMID:25135833
The structure of the Orf 9b protein consisted mostly of beta-sheet, and comprised only few alpha-helix. PMID:19769160
Putative virion assembly protein. PMID:16843897

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Subcellular Location

Virion. Host cytoplasmic vesicle membrane; Peripheral membrane protein. Host cytoplasm. Host endoplasmic reticulum. Host nucleus. Host mitochondrion. Note=Binds non-covalently to intracellular lipid bilayers.

Protein Families

Coronavirus group 2 protein 9b family

Database Links

KEGG: vg:1489679

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