Home
Product
Protein
Recombinant Proteins
Recombinant Human Retinoic acid early transcript 1G protein (RAET1G), partial

Recombinant Human Retinoic acid early transcript 1G protein (RAET1G), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

RAET1G

Purity

>85% (SDS-PAGE)

Target Names

RAET1G

Uniprot NO.

Q6H3X3

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.; Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.; Stimulates natural killer cells to secrete IFNG.

Gene References into Functions

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells. PMID:25212604
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID:20379614
RAET1G is regulated post-translationally to produce a GPI-anchored isoform PMID:20304922
Observational study of genotype prevalence. (HuGE Navigator) PMID:20219610
Binds the activating receptor NKG2D and the the human cytomegalovirus protein UL16. PMID:15240696
the expression patterns of ULBP5RAET1G are very similar to the well-characterised NKG2D ligand, MICA. However the two isoforms of ULBP5/RAET1G have very different cellular localisations that are likely to reflect unique functionality. PMID:19223974
RAET1G, like ULBP2, appears broadly expressed, but exhibits a lower apparent avidity for NKG2D due to a mutation in the center of the MHC-like fold. PMID:19424970
Observational study of genotype prevalence. (HuGE Navigator) PMID:19688209

Hide All

Subcellular Location

[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.; [Isoform 2]: Secreted.

Protein Families

MHC class I family

Tissue Specificity

Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.

Database Links

HGNC: 16795

UNIGENE: Hs.535023

KEGG: hsa:353091

STRING: 9606.ENSP00000356329

OMIM: 609244

Promotions