Recombinant Human Protein phosphatase 1D (PPM1D)

1. The observations suggest a novel role of ATR kinase in mediating its own signal attenuation via PPM1D recruitment to chromatin as an essential mechanism for restarting the stalled forks, cell cycle re-entry and cellular recovery from replication stress. PMID:29485113
2. NF-kappaB served as a positive transcriptional regulator of WIP1 to activate its expression and affect its function in colorectal cancer cells. PMID:29367109
3. ese results enhance our understanding of the molecular mechanisms that govern nucleoli formation by demonstrating that PPM1D regulates nucleolar formation by regulating NPM phosphorylation status through a novel signalling pathway, PPM1D-CDC25C-CDK1-PLK1 PMID:27619510
4. These data support the notion that Wip1 contributes to the formation of the ERMs in PDR membranes via NF-kappaB signaling. PMID:28402943
5. In an in vitro model of the blood-brain barrier, LPS raised Wip1 expression. Wip1 knockdown increased permeability and decreased transepithelial electrical resistance, protein expression of ZO-1, and occluding. Wip1 silencing augmented TNF-alpha, IL-1beta, IL-12, and IL-6. Sonic hedgehog signaling was activated by Wip1 overexpression and inhibited by silencing. Wip1 may protect the BBB against LPS damage via SHH signal... PMID:29128669
6. Studies suugest Wip1 role in tumorigenesis through regulation of p53 and p38MAPK pathways. PMID:26883196
7. The inhibition of Wip1 might fortify p53-mediated tumor suppression by Mdm2 antagonists. PMID:27183917
8. Wip1 suppressed ovarian cancer cell invasion, migration, epithelial to mesenchymal transition (EMT), and ovarian cancer metastasis in xenograft animal models. PMID:27121065
9. model reproduces the observed cellular phenotypes in experiments: oscillatory (for low DNA damage) regulated by negative feedback loops involving mainly p53 and Mdm2 and apoptotic or senescent (for high DNA damage) regulated by the positive p53/Wip1/miR-16 feedback loop PMID:28968438
10. This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB. PMID:27086929
11. Wip1 activity and its relevance to cancer as an oncoprotein is reviewed PMID:28385459
12. The authors show that a global spread of ATM activity on chromatin and phosphorylation of ATM targets including KAP1 control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, allowing cell cycle restart despite persistent ATM activity present at DNA lesions. PMID:28607002
13. Truncating and missense PPM1D mutations are associated with prostate cancer. PMID:27401275
14. this study shows that expression of Wip1 is decreased in patients with active inflammatory bowel disease PMID:27687530
15. Wip1 is frequently overexpressed in nonsmall cell lung cancer, which may serve an essential role in the p38MAPK/p53/p16 signaling pathway. PMID:27959454
16. Study identified 14 individuals with mild to severe Intellectual Disability (ID) and/or developmental delay and de novo truncating PPM1D mutations; all mutations were located in the last or penultimate exon, suggesting escape from nonsense-mediated mRNA decay. PMID:28343630
17. PPM1D gene silencing combined with TMZ eradicates glioma cells through cell apoptosis and cell cycle arrest PMID:27633132
18. High PPM1D expression is associated with breast cancer. PMID:27485113
19. PPM1D in the chromosomal location 17q22-24 might be the most relevant candidate gene with respect to a potential functional implication in meningioma progression. PMID:26942600
20. potential prognostic marker and therapeutic target for hepatocellular carcinoma PMID:26809466
21. PPM1D suppresses pancreatic cancer cell apoptosis via inhibition of the p38 MAPK/p53 pathway through both dephosphorylation of p38 MAPK and downregulation of ASPP2. PMID:26714478
22. squalene inhibits the ATM-dependent signaling pathway following DNA damage through intracellular induction of Wip1 expression. PMID:26824362
23. Chemotherapy exposure and age influence the accumulation of PPM1D mutations in the peripheral blood mononuclear cells of ovarian cancer patients. PMID:26847329
24. Knockdown of Wip1 enhances sensitivity to radiation in HeLa cells by inhibiting cell proliferation and inducing apoptosis through activation of p38 MAPK. PMID:26351212
25. Results showed evidence that Wip1 underwent Cdh1-dependent proteolysis during mitosis and sustained Wip1 activity during mitosis, resulting in mitotic delay at the metaphase to anaphase transition. PMID:25649870
26. Study reveals a mechanism of stem cell aging, in which distinct effects of p53 and mTORC1 pathways on HSC aging are governed by Wip1. PMID:25879755
27. WIP1 silencing reduced expression of MMP-9, VEGF-C, cyclin D1, and c-Myc, as well as migration and invasion of salivary adenoid cystic carcinoma cells. WIP1 expression was positively associated with ACC metastasis and prognosis. PMID:25797250
28. Wip1 may be involved in the biological processes of nasopharyngeal cancer cell proliferation, apoptosis, and migration and invasion. PMID:25060857
29. p21 might contribute to positive regulation of WIP1, resulting in dephosphorylation of the histone H2A variant gammaH2AX. PMID:26006237
30. PPM1D plays an important role in promoting CDDP resistance. PMID:25154814
31. data suggests that WIP1 inhibition represents a novel therapeutic approach to neuroblastoma that could be integrated with current chemotherapeutic approaches PMID:25658463
32. ATM kinase and Wip1 phosphatase were identified as opposing regulators of DAXX-S564 phosphorylation and the role of DAXX phosphorylation and DAXX itself are independent of p53-mediated gene expression. PMID:25659035
33. Wip1 protein was increased in kidney carcinoma. PMID:24970693
34. Results show that downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1. PMID:24846322
35. PPM1D plays an important role in the progression of NSCLC. PMID:25412952
36. High PPM1D expression is associated with lung cancer. PMID:25123458
37. The truncating mutations of PPM1D are present in blood DNA of NSCLC patients. PMID:25742468
38. Results demonstrate increased WIP1 expression in metastatic medulloblastomas, and inferior survival in patients with WIP1 high-expressing medulloblastoma. PMID:24632620
39. WIP1 knockdown inhibited the invasiveness of CNE-2 and 5-8F cells and was associated with the down-regulation of the expression of matrix metallopeptidase 9 PMID:24801909
40. Gain-of-function PPM1D mutations are associated with brainstem gliomas. PMID:24880341
41. High PPM1D expression is associated with prostate cancer. PMID:24922655
42. PP4 and Wip1 are differentially required to counteract the p53-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53-mediated responses, respectively PMID:24711418
43. Wip1 may be involved in the biological processes of non small cell lung cancer cell proliferation, cell apoptosis, and cell cycle. PMID:24272082
44. PPM1D plays a crucial role in colorectal carcinoma cell proliferation and colony formation. PMID:23745790
45. PPM1D mutations in the mosaic state predispose women to breast and ovarian cancer in the absence of a family history of cancer PMID:24262437
46. Expression of Wip1 in neutrophils was downregulated quickly after neutrophil activation through JNK-microRNA-16 pathway. It was negatively correlated with inflammatory cytokine productions of neutrophils in sepsis patients. PMID:24395919
47. Genetic variants and mutations of PPM1D control the response to DNA damage. PMID:23907125
48. BAX dephosphorylation of Wip1 phosphatase is an important regulator of resistance to anticancer therapy. PMID:23907458
49. High WIP1 expression is associated with colorectal cancer. PMID:23679302
50. Wip1 plays an important role in the regulation of global heterochromatin silencing and thus is critical in maintaining genome integrity PMID:24135283

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HGNC: 9277

UNIGENE: Hs.286073

KEGG: hsa:8493

STRING: 9606.ENSP00000306682

OMIM: 114480