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Recombinant Human Probable phospholipid-transporting ATPase VA (ATP10A), partial

Recombinant Human Probable phospholipid-transporting ATPase VA (ATP10A), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ATP10A

Uniprot NO.

O60312

Alternative Names

ATP10A; ATP10C; ATPVA; ATPVC; KIAA0566Probable phospholipid-transporting ATPase VA; EC 7.6.2.1; ATPase class V type 10A; Aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).

Gene References into Functions

results suggest that enhanced PC flipping activity due to exogenous ATP10A expression alters the lipid composition at the plasma membrane PMID:25947375
has been proven that hypocaloric diets induce changes in the DNA methylation pattern in PBMCs (CpG18 of ATP10A and CpG 21 of WT1) and that some of these markers could be used as early indicators of response to metabolic effects of weight-loss programs PMID:21209057
ATP10A gene is imprinted, with preferential expression from the maternal allele in human brain. PMID:11353404
report the generation of the complete genomic structure PMID:12105293
In the analysis of a four-marker haplotype located in ATP10C, a statistically significant difference was observed in the frequency of one haplotype between male autism patients and controls PMID:18186074
monoallelic expression of human ATP10A is variable in the population and is influenced by both gender and common genetic variation PMID:18726118

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Tissue Specificity

Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.

Database Links

HGNC: 13542

UNIGENE: Hs.638517

KEGG: hsa:57194

STRING: 9606.ENSP00000349325

OMIM: 105830

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