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Recombinant Human Probable G-protein coupled receptor 75 (GPR75), partial,Mammalian cell

Recombinant Human Probable G-protein coupled receptor 75 (GPR75), partial,Mammalian cell

CSB-MP009829HU

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Express system: Mammalian cell

Species: Homo sapiens (Human)

Tag Info: N-terminal His-tagged and C-terminal Myc-tagged/N-terminal His-tagged/Tag-Free

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Product Details
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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

GPR75

Uniprot NO.

O95800

Research Area

Signal Transduction

Species

Homo sapiens (Human)

Source

Mammalian cell

Mol. Weight

20.9kDa

Protein Length

Partial

Tag Info

N-terminal His-tagged and C-terminal Myc-tagged/N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Description

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Target Background

Function

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cel

Database Links

HGNC: 4526

UNIGENE: Hs.40763

KEGG: hsa:10936

STRING: 9606.ENSP00000378195

OMIM: 606704

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