Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2), partial

1. beta2-adrenoceptors alone strongly enhanced the activity of HCN2 channels, and co-expression of odorant receptors further diversified the HCN2 channel activity. PMID:29054409
2. TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels. PMID:28864772
3. HCN2 has a role in maturation and processing of the amyloid precursor protein PMID:28017718
4. promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC. PMID:27212063
5. Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm. PMID:26005035
6. Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2). PMID:25197093
7. N-glycosylation is not required for HCN2 channels to function. PMID:25423599
8. Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels. PMID:24525276
9. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PMID:24324597
10. HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri-implantitis. PMID:23907424
11. LBB-injected HCN2/SkM1 potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB PMID:23395072
12. HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. PMID:22094222
13. This is the first evidence in humans for a single-point, homozygous loss-of-function mutation in HCN2 potentially associated with generalized epilepsy with recessive inheritance. PMID:22131395
14. Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. PMID:21615589
15. HCN4 activates substantially slower than HCN2 and with a half-maximum activation voltage approximately equal 10 mV less negative, both isoforms activate more positively in myocytes suggesting cell-type specificity PMID:12194012
16. activation of the fast channel HCN2 is dependent on the S1 segment PMID:12813043
17. HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy PMID:12890777
18. Native I(f) channels in atrial myocardium are heteromeric complexes composed of HCN4 and/or HCN2. PMID:15687126
19. Mutations of a putative cyclic-nucleotide-binding domain (CNBD) can disrupt the function of the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN2). PMID:15961404
20. an intact F-actin cytoskeleton is a prerequisite for the swelling-induced HCN2 current PMID:15980171
21. With computer modelling, we show that in channels with relatively slow opening kinetics and fast mode-shift transitions, such as HCN2 and HCN4 channels, the mode shift effects are not readily observable, except in the tail kinetics. PMID:16777944
22. Noise analysis on macroscopic currents revealed fluctuations whose magnitudes were systematically larger than predicted from the actual single channel current size, consistent with cooperativity between single HCN channels. PMID:17043149
23. Several functional variants were identified including the amino acid substitution R527Q in HCN2 exon 5. HCN2 channels containing the R527Q variant demonstrated a trend towards a decreased slope of the conductance-voltage relation. PMID:17931874
24. RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation PMID:18768480

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HGNC: 4846

UNIGENE: Hs.124161

KEGG: hsa:610

STRING: 9606.ENSP00000251287

OMIM: 602781