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Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1), partial

Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

HCN1

Uniprot NO.

O60741

Alternative Names

BCNG-1; BCNG1; Brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC 2; HAC2; HCN1; HCN1_HUMAN; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium channel; voltage-gated; brain; 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.

Gene References into Functions

Polymorphism of HCN1 is associated with breast cancer. PMID:28178648
Study presents cryo-electron microscopy structures of the human HCN1 channel in the absence and presence of cAMP at 3.5 A resolution. HCN channels contain a K(+) channel selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na(+) and K(+) permeability. PMID:28086084
A new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway. PMID:25142030
de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans PMID:24747641
acute abrogation of HCN1-FLNa interaction in neurons, with the use of decoy peptides that mimic the FLNa-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies PMID:24403084
Studies suggest that HCN1 channels may be therapeutic targets for treatment of depressive disorders. PMID:23033536
Wild-type presynaptic HCN1 channel function is persistently decreased following seizures. PMID:23077068
HCN1 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. PMID:22094222
Hyperpolarization-activated currents are smaller and slower, input resistances are higher, and membrane time constants are longer in HCN1-deficient than in HCN1-expressing neurons of the ventral cochlear nucleus. PMID:21562186
Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. PMID:21615589
increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively. PMID:21504900
Human HCN1 hyperpolarization activated current (Ih) amplitude is rapidly enhanced after establishment of the whole-cell configuration in HEK293 cells. PMID:20806410
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID:20145138
Helical secondary structure of the external S3-S4 linker of this pacemaker channel is examined and affects its activation PMID:12668666
HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy PMID:12890777
In HCN1, the amino acid substitution A881T was identified in one idiopathic generalized epilepsy patient. PMID:17931874
The polymorphism rs10941679 near HCN1/MRPS30 was also associated with percent dense area in breast cancer. PMID:19232126
Observational study of gene-disease association. (HuGE Navigator) PMID:19232126
Observational study of gene-disease association. (HuGE Navigator) PMID:18454440
Observational study of gene-disease association. (HuGE Navigator) PMID:17931874
Observational study of gene-disease association. (HuGE Navigator) PMID:18081024

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Potassium channel HCN family

Tissue Specificity

Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.

Database Links

HGNC: 4845

UNIGENE: Hs.353176

KEGG: hsa:348980

STRING: 9606.ENSP00000307342

OMIM: 602780

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