Home
Product
Protein
Recombinant Proteins
Recombinant Human Potassium channel subfamily U member 1 (KCNU1), partial

Recombinant Human Potassium channel subfamily U member 1 (KCNU1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

KCNU1

Uniprot NO.

A8MYU2

Alternative Names

subfamily M subunit alpha-3; Calcium activated potassium channel subfamily M subunit alpha 3; Calcium activated potassium channel subunit alpha 3; Calcium-activated potassium channel; Calcium-activated potassium channel subunit alpha-3; KCa5; KCa5.1; Kcnma3; KCNMC1; KCNU 1; KCNU1; KCNU1_HUMAN; Potassium channel subfamily U member 1; Slo3; Slowpoke homolog 3

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Gene References into Functions

results suggest that sperm-specific genes can evolve rapidly and that natural genetic variation may have led to a SLO3 variant that differs from wild type in both pH and intracellular Ca(2+) sensitivities. PMID:28377504
The authors conclude that Slo3 represents the principal K(+) channel in human sperm that carries the Ca(2+)-activated IKSper current. PMID:24670955
These results present insights into the function of a protein expected to be critical for human reproduction and provide a framework to study the mechanism of pH gating in SLO3 channels. PMID:23129643

Hide All

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa5.1/KCNU1 sub-subfamily

Tissue Specificity

Testis-specific.

Database Links

HGNC: 18867

UNIGENE: Hs.13861

KEGG: hsa:157855

STRING: 9606.ENSP00000382770