Recombinant Human Nuclear receptor coactivator 2 (NCOA2), partial

1. Using quantitative biochemical, biophysical, and solution structural methods study shows that ligand and DNA cooperatively recruit the intrinsically disordered steroid receptor coactivator-2 (SRC-2/TIF2/GRIP1/NCoA-2) receptor interaction domain to peroxisome proliferator-activated receptor gamma-retinoid X receptor alpha (PPARgamma-RXRalpha) heterodimer and reveal the binding determinants of the complex. PMID:28890360
2. T3 promotes differentiation towards chondrocytes-like cells in our in vitro model, that this differentiation is mediated by steroid receptor co-activator 2 (SRC2) and does not induce hypertrophy PMID:26869487
3. Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion. PMID:27544802
4. Data suggest that steroid receptor coactivators (NCOA1, NCOA2, NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW] PMID:28390937
5. SRC-2 may exhibit oncogenic or tumor suppressor activity depending on the target genes and nuclear receptors that are expressed in distinct tissues PMID:28273073
6. NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 domain of NCOA2 and the ETS DNAbinding domain of ETV4. PMID:27633981
7. Altered expression of TIF2 may play a role in adenomyosis development and treatment outcome with levonorgestrel-releasing intrauterine system. PMID:26040939
8. evaluating if NCOA2 relative copy-number gain presents prognostic value for prostate cancer PMID:26799514
9. Report NcoA2-regulation of the AhR-ARNT-HIF-1a interaction. PMID:26350169
10. Data suggest that LRH1/NR5A2 (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 and SHP (co-repressor; small heterodimer partner protein). PMID:26553876
11. NCOA2 is a novel negative growth regulatory gene repressing the Wnt/beta-catenin pathway in colorectal cancer, where recurrent fusion with LACTB2 contributes to its disruption. PMID:25823027
12. Suggest a possible association between NCOA2 rs10504473 polymorphism and obesity in Chinese Han population. PMID:26261634
13. miR-137 has a role in targeting p160 steroid receptor coactivators SRC1, SRC2, and SRC3 and inhibits cell proliferation PMID:26066330
14. results suggest that CCNC temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes. PMID:25986860
15. Data suggest that over-stimulating the steroid seceptor coactivators SRC-1, SRC-2, and SRC-3 oncogenic program can be an effective strategy to kill cancer cells. PMID:26267537
16. SRC-2 is a prominent metabolic coordinator of cancer metastasis. PMID:25664849
17. Because deregulation of endometrial SRC-2 expression has been associated with common gynecological disorders of reproductive-age women, this signaling pathway, involving SRC-2 and PFKFB3. PMID:24204309
18. the PAX3-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma PMID:24213582
19. increased levels of SRC-2 impairs murine endometrial function PMID:24905738
20. NCOA1 plays a necessary role in E2-induced CXCL12 expression and NCOA2 is required for P4 to inhibit the E2-induced CXCL12 production in normal and ectopic endometrium. PMID:24586072
21. Transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that requires SRC-2 for full induction. PMID:24571987
22. The combination of NCOA2 FISH and Stat6 IHC proved effective for the differential diagnosis of soft-tissue angiofibroma, even when using small biopsy specimens. PMID:24856853
23. MOZ-TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia. PMID:24258712
24. Data show the networks of interactions that connect retinoid X receptor alpha (RXRalpha) agonists to coactivator GRIP1 binding. PMID:24187139
25. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells. PMID:23936147
26. HBO1, but not SRC-2, expression was reduced in testes of patients with androgen insensitivity syndromes compared to normal testes. PMID:23707616
27. The identification of HEY1-NCOA2 can be used as an auxiliary diagnostic tool to differentiate meningeal hemangiopericytoma from mesenchymal chondrosarcoma. PMID:24124145
28. Recurrent NCOA2 gene rearrangements is associated with congenital/infantile spindle cell rhabdomyosarcoma PMID:23463663
29. Transactivation of glucocorticoid receptor-interacting protein 1 transactivation was stimulated to a similar degree by promyelocytic leukemia protein. PMID:23542129
30. cAMP response element-binding protein (CREB) downregulates GRIP1 and is necessary for the PKA-stimulated degradation of GRIP1, which leads to changes in the expression of a subset of genes regulated by estrogen receptor-alpha in MCF-7 breast cancer cells. PMID:23462962
31. the cellular accumulation of IRF-1 may represent a potential molecular mechanism mediating altered cellular response to GC through the depletion of GRIP-1 from the GR transcriptional regulatory complexes PMID:19805480
32. dissect the GRIP1:Suv4-20h1 interaction in vitro and in vivo and examine its potential involvement in hormone-dependent transcriptional regulation by GR PMID:19074285
33. The initial stimulation of GRIP1 coactivator function is followed by an increased turnover and subsequent degradation of GRIP1 protein. PMID:18499756
34. CoCoA uses different combinations of functional domains in its synergistic coactivator function with beta-catenin or GRIP1 PMID:16344550
35. modulation of nuclear receptor interaction domain by covalent attachment of SUMO-1 PMID:12060666
36. The current study adds further support for the use of HEY1-NCOA2 fusion as a valid diagnostic marker for Mesenchymal chondrosarcoma PMID:23252872
37. Overexpression of SRC-1 (NCOA1) and TIF-2 (NCOA2) increases estrogen-induced gene expression. PMID:12403846
38. Binding of the N-terminal region of TIF2 to the AF1 domain of the glucocorticoid receptor changes both its conformation and transcriptional activity. PMID:23132854
39. The crystal structure of RXRA-ligand binding domain:9-cis-retinoic acid:GRIP1 is reported at 2.05 A. PMID:21049972
40. findings suggest that TIF2 is a novel binding partner for nuclear EGFR and is involved in regulating its target gene expression. PMID:22581837
41. a substantial subset of soft tissue angiofibroma is characterized by a t(5;8)(p15;q13), resulting in the expression of in-frame AHRR/NCOA2 and NCOA2/AHRR fusion transcripts. PMID:22337624
42. Univariate survival analysis revealed that high tif2 expression was associated with worse prognosis in astrocytic brain tumors PMID:21735116
43. The novel HEY1-NCOA2 fusion appears to be the defining and diagnostic gene fusion in mesenchymal chondrosarcomas PMID:22034177
44. Genetic aberrations and dysregulation in expression of p160/SRC coactivators and the ANCCA in breast cancer, prostate cancer, and other nonhormone-responsive cancers, are reviewed. PMID:20374707
45. Treatment of THP-1 cells with coenzyme Q10 significantly decreased expression of NCOA2. PMID:21370964
46. we detected NCOA2 mutations neither in prostate cancers nor in other cancers PMID:21492233
47. Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line. PMID:21059860
48. SRC-2 and SRC-3 concomitantly promote human adipocyte differentiation by attenuating phospho-PPARgamma-Serine114 and modulating PPARgamma cellular heterogeneity. PMID:21220509
49. the hepatic AMPK-SRC-2 axis as an energy rheostat PMID:21195347
50. MOZ-TIF2 oncogenic fusion protein suppresses transcription by nuclear receptors and p53 PMID:15657427

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HGNC: 7669

UNIGENE: Hs.446678

KEGG: hsa:10499

STRING: 9606.ENSP00000399968

OMIM: 601993