Recombinant Human Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3), partial

1. MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRA PMID:28627449
2. The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. PMID:28724635
3. we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism PMID:28125639
4. the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells. PMID:27697837
5. Calcineurin together with its upstream molecule, calpain 2, and its downstream effector, NFAT-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes. PMID:27123462
6. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis PMID:25215946
7. Suggest nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation. PMID:25422138
8. Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3). PMID:24582564
9. AP-1 and NFAT4 complex promotes miR-23a expression. PMID:23929433
10. The closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation. PMID:23219532
11. Data indicate that NFATc3 undergoes rapid dephosphorylation and nuclear translocation that are essentially complete within 20 min, although NFATc4 remains phosphorylated and localized to the cytosol. PMID:22977251
12. Abeta-activated NFAT4 proteins were associated with astrocytic BACE1 gene expression via direct interaction with the BACE1 promoter region. PMID:22846573
13. The authors report that NFAT4 and NF-kappaB interact at the KB element to co-operatively activate both human polyomavirus JC early and late transcription and viral DNA replication. PMID:22749879
14. NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell proliferation and NFATc3 regulates COX2 in endothelial cells PMID:21642596
15. transactivation activity and role in inducing differentiation of CD4(+)CD8(+) T cells PMID:11997392
16. NFAT and thyroid transcription factor-1 have roles in regulating transcription of the surfactant protein D gene PMID:15173172
17. NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj PMID:16260608
18. We found that [Ca(2+)](i) oscillations were associated with NFAT translocation into the nucleus in undifferentiated hMSCs. As the hMSCs differentiated to adipocytes, the [Ca(2+)](i) oscillations disappeared and the translocation of NFAT ceased. PMID:16445977
19. Calcium signaling and the activation of NFAT in glial cells are required for JC Virus infection of the CNS. PMID:17035332
20. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID:18815128

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HGNC: 7777

UNIGENE: Hs.436585

KEGG: hsa:4775

STRING: 9606.ENSP00000300659

OMIM: 602698