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Recombinant Human Ninein-like protein (NINL), partial

Recombinant Human Ninein-like protein (NINL), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

NINL

Purity

>85% (SDS-PAGE)

Target Names

NINL

Uniprot NO.

Q9Y2I6

Alternative Names

NINL; KIAA0980; NLP; Ninein-like protein

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-1382

Target Protein Sequence

MDEEENHYVS QLREVYSSCD TTGTGFLDRQ ELTQLCLKLH LEQQLPVLLQ TLLGNDHFAR VNFEEFKEGF VAVLSSNAGV RPSDEDSSSL ESAASSAIPP KYVNGSKWYG RRSRPELCDA ATEARRVPEQ QTQASLKSHL WRSASLESVE SPKSDEEAES TKEAQNELFE AQGQLQTWDS EDFGSPQKSC SPSFDTPESQ IRGVWEELGV GSSGHLSEQE LAVVCQSVGL QGLEKEELED LFNKLDQDGD GKVSLEEFQL GLFSHEPALL LESSTRVKPS KAWSHYQVPE ESGCHTTTTS SLVSLCSSLR LFSSIDDGSG FAFPDQVLAM WTQEGIQNGR EILQSLDFSV DEKVNLLELT WALDNELMTV DSAVQQAALA CYHQELSYQQ GQVEQLARER DKARQDLERA EKRNLEFVKE MDDCHSTLEQ LTEKKIKHLE QGYRERLSLL RSEVEAEREL FWEQAHRQRA ALEWDVGRLQ AEEAGLREKL TLALKENSRL QKEIVEVVEK LSDSERLALK LQKDLEFVLK DKLEPQSAEL LAQEERFAAV LKEYELKCRD LQDRNDELQA ELEGLWARLP KNRHSPSWSP DGRRRQLPGL GPAGISFLGN SAPVSIETEL MMEQVKEHYQ DLRTQLETKV NYYEREIAAL KRNFEKERKD MEQARRREVS VLEGQKADLE ELHEKSQEVI WGLQEQLQDT ARGPEPEQMG LAPCCTQALC GLALRHHSHL QQIRREAEAE LSGELSGLGA LPARRDLTLE LEEPPQGPLP RGSQRSEQLE LERALKLQPC ASEKRAQMCV SLALEEEELE LARGKRVDGP SLEAEMQALP KDGLVAGSGQ EGTRGLLPLR PGCGERPLAW LAPGDGRESE EAAGAGPRRR QAQDTEATQS PAPAPAPASH GPSERWSRMQ PCGVDGDIVP KEPEPFGASA AGLEQPGARE LPLLGTERDA SQTQPRMWEP PLRPAASCRG QAERLQAIQE ERARSWSRGT QEQASEQQAR AEGALEPGCH KHSVEVARRG SLPSHLQLAD PQGSWQEQLA APEEGETKIA LEREKDDMET KLLHLEDVVR ALEKHVDLRE NDRLEFHRLS EENTLLKNDL GRVRQELEAA ESTHDAQRKE IEVLKKDKEK ACSEMEVLNR QNQNYKDQLS QLNVRVLQLG QEASTHQAQN EEHRVTIQML TQSLEEVVRS GQQQSDQIQK LRVELECLNQ EHQSLQLPWS ELTQTLEESQ DQVQGAHLRL RQAQAQHLQE VRLVPQDRVA ELHRLLSLQG EQARRRLDAQ REEHEKQLKA TEERVEEAEM ILKNMEMLLQ EKVDKLKEQF EKNTKSDLLL KELYVENAHL VRALQATEEK QRGAEKQSRL LEEKVRALNK LVSRIAPAAL SV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

Gene References into Functions

Upon UVC radiation, Nlp interacts with XPA and ERCC1, and enhances their association PMID:26805762
these data support a model where CC2D2A associates with NINL to provide a docking point for cilia-directed cargo vesicles, suggesting a mechanism by which transition zone proteins can control the protein content of the ciliary compartment. PMID:26485645
Overexpression of ninein and the ninein-like protein NIP induces fragmentation of the Golgi and causes lysosomes to disperse toward the cell periphery. PMID:16254247
Breast cancer patients with high expression of Nlp were likely resistant to the treatment of paclitaxel. PMID:22353935
This review summarises our current knowledge of physiological roles of Nlp, with an emphasis on its potentials in tumourigenesis. PMID:21505454
findings demonstrate that Cdc2/cyclin B1 is a key regulator in maintaining appropriate degradation and subcellular localization of Nlp, providing novel insights into understanding on the role of Cdc2/cyclin B1 in mitotic progression PMID:20890132
regulation of Nlp by Aurora B is critical for the completion of cytokinesis, providing novel insights into understanding the machinery of cell cycle progression. PMID:20864540
Nlp abnormalities may contribute to genomic instability and tumorigenesis and might serve as a potential biomarker for clinical diagnosis and as a therapeutic target. PMID:20093778
results indicate that ninein-like protein expression is cell cycle-dependent and regulated by anaphase-promoting cyclosome complex-mediated protein degradation PMID:17403670
Overexpression of Nlp in ovarian tumors raises the possibility that Nlp may play a role in ovarian carcinogenesis. PMID:18538832
Nlp(isoB)interacts with USH2A and lebercilin. PMID:18826961
BRCA1 interaction of Nlp might be required for the successful mitotic progression, and abnormalities of Nlp lead to genomic instability. PMID:19509300
Nlp overexpression might contribute to the development of head and neck squamous cell carcinoma PMID:19724857

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Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm (PubMed:16254247).

Tissue Specificity

Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lun

Database Links

HGNC: 29163

UNIGENE: Hs.631508

KEGG: hsa:22981

STRING: 9606.ENSP00000278886

OMIM: 609580

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