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Recombinant Human NLR family member X1 (NLRX1), partial

Recombinant Human NLR family member X1 (NLRX1), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

NLRX1

Purity

>85% (SDS-PAGE)

Target Names

NLRX1

Uniprot NO.

Q86UT6

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

87-975

Target Protein Sequence

AEWF SRLPREERQF GPTFALDTVH VDPVIRESTP DELLRPPAEL ALEHQPPQAG LPPLALSQLF NPDACGRRVQ TVVLYGTVGT GKSTLVRKMV LDWCYGRLPA FELLIPFSCE DLSSLGPAPA SLCQLVAQRY TPLKEVLPLM AAAGSHLLFV LHGLEHLNLD FRLAGTGLCS DPEEPQEPAA IIVNLLRKYM LPQASILVTT RPSAIGRIPS KYVGRYGEIC GFSDTNLQKL YFQLRLNQPY CGYAVGGSGV SATPAQRDHL VQMLSRNLEG HHQIAAACFL PSYCWLVCAT LHFLHAPTPA GQTLTSIYTS FLRLNFSGET LDSTDPSNLS LMAYAARTMG KLAYEGVSSR KTYFSEEDVC GCLEAGIRTE EEFQLLHIFR RDALRFFLAP CVEPGRAGTF VFTVPAMQEY LAALYIVLGL RKTTLQKVGK EVAELVGRVG EDVSLVLGIM AKLLPLRALP LLFNLIKVVP RVFGRMVGKS REAVAQAMVL EMFREEDYYN DDVLDQMGAS ILGVEGPRRH PDEPPEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD ALENAQAIKK KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLSSLRQ LNLAGVRMTP VKCTVVAAVL GSGRHALDEV NLASCQLDPA GLRTLLPVFL RARKLGLQLN SLGPEACKDL RDLLLHDQCQ ITTLRLSNNP LTAAGVAVLM EGLAGNTSVT HLSLLHTGLG DEGLELLAAQ LDRNRQLQEL NVAYNGAGDT AALALARAAR EHPSLELLHL YFNELSSEGR QVLRDLGGAA EGGARVVVSL TEGTAVSEYW SVILSEVQRN LNSWDRARVQ RHLELLLRDL EDSRGATLNP WRKAQLLRVE GEVRALLEQL GSSGS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.

Gene References into Functions

Data show that NLRX1 specifically interacts with FASTKD5 and colocalizes with mitochondrial RNA granules. Further results suggest an important role of NLRX1 in regulating the post-transcriptional processing of mitochondrial RNA, which may have an important implication in bioenergetic adaptation during metabolic stress, oncogenic transformation and innate immunity. PMID:29932989
genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (TRAF6 = TNF receptor associated factor-6) PMID:29046236
Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma. PMID:27105514
NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3. NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. PMID:28967880
downregulated in brain injury following aneurysm PMID:28993512
The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission. PMID:28459883
we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID:26876213
findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis PMID:27393910
NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review) PMID:26763980
NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha induced cell death and metabolism. PMID:25639646
These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID:25938787
Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation. PMID:24429360
NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID:23321557
Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID:22610944
Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. PMID:22718770
NLRX1 attenuated IFN-I production & promoted autophagy during viral infection cells. NLRX1 interacts with TUFM. PMID:22749352
NLRX1 interacts directly with RNA and suggestts a role for NLRX1 in recognition of intracellular viral RNA in antiviral immunity. PMID:22386589
the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID:20959452
function of NOD-like receptors in the antiviral response [REVIEW] PMID:18466630
identification of NLRX1 as a check against mitochondrial antiviral responses--an intersection of three ancient cellular processes: NLR signalling, intracellular virus detection and the use of mitochondria as a platform for anti-pathogen signalling PMID:18200010
These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses. PMID:18219313
sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity PMID:18397740
NLRX1 has a functional leader sequence and fully translocates to the mitochondrial matrix. PMID:19692591

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Subcellular Location

Mitochondrion outer membrane.

Protein Families

NLRP family

Tissue Specificity

Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).

Database Links

HGNC: 29890

UNIGENE: Hs.524082

KEGG: hsa:79671

STRING: 9606.ENSP00000292199

OMIM: 611947

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