Home
Product
Protein
Recombinant Proteins
Recombinant Human NKG2D ligand 4 (RAET1E), partial

Recombinant Human NKG2D ligand 4 (RAET1E), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

RAET1E

Purity

>85% (SDS-PAGE)

Target Names

RAET1E

Uniprot NO.

Q8TD07

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene References into Functions

decreased expression levels of ULBP4 in NPC tissues as compared to that in normal NP epithelial tissues. In addition, low ULBP4 expression correlated with poor OS, DFS, DMFS, and may prove to be a novel prognostic factor. PMID:28159927
Blocking the interaction of NKG2D with its ligands deleted the sensitizing effects of HCQ. In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane PMID:28339029
5 of the 7 promoter polymorphisms of the RAET1E gene may disrupt transcription factor binding PMID:26519211
RAET1E promoter polymorphism has increased to nine types, and there are now 12 alleles determined by the coding exons, including one null. PMID:26814419
Patients whose tumors had high expression of RAET1E, ULBP1 and ULBP3 surviving a median of 11, 14 and 11 months, respectively, compared with disease-specific survival of 29, 30 and 25 months in patients whose tumors showed no expression of these ligands PMID:20054857
Binds the activating receptor NKG2D. PMID:15240696
immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D-mediated NK cell cytotoxicity to tumors PMID:17470428
All ULBP4 splice variants (ULBP4-I, ULBP4-II and ULBP4-III) were type 1 membrane-spanning molecules and had the ability to bind with human NKG2D receptor in vitro PMID:18544572
data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D and may play a key role in immune surveillance of tumor development and clearance of viral infection PMID:19436053

Hide All

Subcellular Location

Membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted.

Protein Families

MHC class I family

Tissue Specificity

Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.

Database Links

HGNC: 16793

UNIGENE: Hs.511818

KEGG: hsa:135250

STRING: 9606.ENSP00000349709

OMIM: 609243

Promotions