Recombinant Human NKG2D ligand 3 (ULBP3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

ULBP3

Purity

>85% (SDS-PAGE)

Target Names

ULBP3

Uniprot NO.

Q9BZM4

Alternative Names

ULBP3; N2DL3; RAET1N; UL16-binding protein 3; ALCAN-gamma; NKG2D ligand 3; N2DL-3; NKG2DL3; Retinoic acid early transcript 1N

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

30-217

Target Protein Sequence

D AHSLWYNFTI IHLPRHGQQW CEVQSQVDQK NFLSYDCGSD KVLSMGHLEE QLYATDAWGK QLEMLREVGQ RLRLELADTE LEDFTPSGPL TLQVRMSCEC EADGYIRGSW QFSFDGRKFL LFDSNNRKWT VVHAGARRMK EKWEKDSGLT TFFKMVSMRD CKSWLRDFLM HRKKRLEPTA PPTMAPG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene References into Functions

this study shows an increase in ULBP3 level in alopecia areata incognita patients, which positively correlates with the age and duration of the disease PMID:27142445
Varicella-Zoster Virus differentially modulates expression of the NKG2D ligands by upregulating MICA expression and reducing ULBP2 and ULBP3 expression in the infected cells. PMID:25995251
This study provides for the first time, the c-Myc dependent regulation of NKG2D ligands, ULBP1/2/3 in acute myeloid leukemia. PMID:24677544
A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease PMID:21689246
A miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. PMID:21320692
genetic polymorphism among the ethnic groups PMID:20219610
Data show that UL142 prevents ULBP3 trafficking to the surface and protects transfected cells from NK-mediated cytotoxicity. PMID:20530255
As NKG2D ligand, ULBP3 are expressed on immature and mature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID:18394338
ULBP3 binds to the NGK2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID:11777960
ULBPs and MICA are expressed in lipid rafts at the cell surface of NK and T cells. PMID:15051759
Vpr specifically induces surface expression of the unique-long 16 binding proteins (ULBP)-1 and ULBP-2, but not ULBP-3 PMID:19798433