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Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3), partial

Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

MAGI3

Purity

>85% (SDS-PAGE)

Target Names

MAGI3

Uniprot NO.

Q5TCQ9

Alternative Names

dJ730K3.2; MAGI-3; magi3; MAGI3_HUMAN; Membrane Associated Guanylate kinase Related 3; Membrane associated guanylate kinase, WW and PDZ domain containing 3; Membrane associated guanylate kinase, WW and PDZ domain containing protein 3; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 3; RP4-730K3.1; SLIPR; WW and PDZ domain-containing protein 3

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-1506

Target Protein Sequence

MSKTLKKKKH WLSKVQECAV SWAGPPGDFG AEIRGGAERG EFPYLGRLRE EPGGGTCCVV SGKAPSPGDV LLEVNGTPVS GLTNRDTLAV IRHFREPIRL KTVKPGKVIN KDLRHYLSLQ FQKGSIDHKL QQVIRDNLYL RTIPCTTRAP RDGEVPGVDY NFISVEQFKA LEESGALLES GTYDGNFYGT PKPPAEPSPF QPDPVDQVLF DNEFDAESQR KRTTSVSKME RMDSSLPEEE EDEDKEAING SGNAENRERH SESSDWMKTV PSYNQTNSSM DFRNYMMRDE TLEPLPKNWE MAYTDTGMIY FIDHNTKTTT WLDPRLCKKA KAPEDCEDGE LPYGWEKIED PQYGTYYVDF TLVAQAGVQW HDLGSLQPPP PGFNHLNQKT QFENPVEEAK RKKQLGQVEI GSSKPDMEKS HFTRDPSQLK GVLVRASLKK STMGFGFTII GGDRPDEFLQ VKNVLKDGPA AQDGKIAPGD VIVDINGNCV LGHTHADVVQ MFQLVPVNQY VNLTLCRGYP LPDDSEDPVV DIVAATPVIN GQSLTKGETC MNPQDFKPGA MVLEQNGKSG HTLTGDGLNG PSDASEQRVS MASSGSSQPE LVTIPLIKGP KGFGFAIADS PTGQKVKMIL DSQWCQGLQK GDIIKEIYHQ NVQNLTHLQV VEVLKQFPVG ADVPLLILRG GPPSPTKTAK MKTDKKENAG SLEAINEPIP QPMPFPPSII RSGSPKLDPS EVYLKSKTLY EDKPPNTKDL DVFLRKQESG FGFRVLGGDG PDQSIYIGAI IPLGAAEKDG RLRAADELMC IDGIPVKGKS HKQVLDLMTT AARNGHVLLT VRRKIFYGEK QPEDDSSQAF ISTQNGSPRL NRAEVPARPA PQEPYDVVLQ RKENEGFGFV ILTSKNKPPP GVIPHKIGRV IEGSPADRCG KLKVGDHISA VNGQSIVELS HDNIVQLIKD AGVTVTLTVI AEEEHHGPPS GTNSARQSPA LQHRPMGQSQ ANHIPGDRSA LEGEIGKDVS TSYRHSWSDH KHLAQPDTAV ISVVGSRHNQ NLGCYPVELE RGPRGFGFSL RGGKEYNMGL FILRLAEDGP AIKDGRIHVG DQIVEINGEP TQGITHTRAI ELIQAGGNKV LLLLRPGTGL IPDHGDWDIN NPSSSNVIYD EQSPLPPSSH FASIFEESHV PVIEESLRVQ ICEKAEELKD IVPEKKSTLN ENQPEIKHQS LLQKNVSKRD PPSSHGHSNK KNLLKVENGV TRRGRSVSPK KPASQHSEEH LDKIPSPLKN NPKRRPRDQS LSPSKGENKS CQVSTRAGSG QDQCRKSRGR SASPKKQQKI EGSKAPSNAE AKLLEGKSRR IAGYTGSNAE QIPDGKEKSD VIRKDAKQNQ LEKSRTRSPE KKIKRMVEKS LPSKMTNKTT SKEVSENEKG KKVTTGETSS SNDKIGENVQ LSEKRLKQEP EEKVVSNKTE DHKGKELEAA DKNKETGRFK PESSSPVKKT LITPGPWKVP SGNKVTGTIG MAEKRQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Gene References into Functions

Study shows that MAGI3 undergoes premature polyadenylation (pPA) at the intron immediately downstream of its large internal exon, which is normally highly modified by N(6)-methyladenosine (m(6)A). In breast cancer cells that upregulate MAGI3 (pPA) , m(6)A levels in the large internal exon of MAGI3 are significantly reduced compared to cells that do not express MAGI3 (pPA). MAGI3 (pPA) transcripts are depleted of m(6)A. PMID:29362392
Our findings lend support to a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3 as a new candidate gene for IBD. PMID:28545409
The altered mRNA isoform, called MAGI3(pPA), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP oncoprotein, thereby relieving YAP inhibition and promoting malignant transformation of human mammary epithelial cells. PMID:27205883
Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma. PMID:26452219
Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas. PMID:26248734
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells. PMID:21134377
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID:20379614
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation [MAGI-2, MAGI-3] PMID:12140759
In epithelial cells, MAGI-3 was localized with ZO-1 and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin-based cell-cell contacts and in focal adhesion sites. PMID:12615970
These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA. PMID:16904289
All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 and MAGI-3 PMID:18518978