Home
Product
Protein
Recombinant Proteins
Recombinant Human MACRO domain-containing protein 2 (MACROD2)

Recombinant Human MACRO domain-containing protein 2 (MACROD2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

MACROD2

Uniprot NO.

A1Z1Q3

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-448

Target Protein Sequence

MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD VEMNSQVDKV NDPTESQQED QLIAGAQDEA KEQRNGTK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.

Gene References into Functions

In patients with Graves' disease, a common genetic variant in MACROD2 may increase susceptibility for thyroid-associated orbitopathy. PMID:27304844
ATM induces MacroD2 nuclear export upon DNA damage. PMID:28069995
MACROD2 gene is a strong positional candidate risk factor for autistic-like traits in the general population PMID:25360606
MACROD2 is a key mediator of estrogen independent growth and tamoxifen resistance PMID:25422431
this study does not provide support for the reported association between rs4141463, within the MACROD2 gene and autism. PMID:21656903
An analysis of 1 million single-nucleotide polymorphisms found a possible commonality for autism in the allele at rs4141463 located in MACROD2. PMID:20663923
A 250 kb de novo microdeletion at 20p12.1, deleting exon 5 of C20orf133, was seen in a Kabuki syndrome case. The de novo deletion, the expression data & the fact that C20orf133 has a macro domain make it a likely candidate to cause KS in this patient. PMID:17586838
Authors describe the results of a deletion assay for the exon 5 in C20orf133 and a mutation analysis of C20orf133 and FLRT3 in patients with Kabuki Syndrome. PMID:18593871