Recombinant Human Low-density lipoprotein receptor-related protein 1B (LRP1B), partial

1. LRP1B mutations are highly prevalent among the lung adenocarcinoma patients with COPD. PMID:28522810
2. Data show that overexpression of full-length mouse Lrp1b leads to impaired cellular proliferation, while humsn LRP1B knockdown has the opposite effect. PMID:27626682
3. that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling PMID:28408316
4. LRP1B gene is a target for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma. PMID:27636103
5. LRP1B, BRD2 and CACNA1D are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia. PMID:26586120
6. LRP1B presents with frequent molecular alterations for glioblastoma patients; its deletion may impact patient outcome. PMID:26428308
7. Silencing of LRP1B altered the expression of focal adhesion complex-associated proteins, and Cdc42/RhoA activities. PMID:23521319
8. genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: LRP1B (rs2890652) is associated with body mass index and insulin resistance. PMID:21953277
9. LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE--carrying lipoproteins PMID:21420681
10. Epigenomics and microRNAs inactivate LRP1B, a modulator of the extracellular environment of thyroid cancer cells, and it is deleted in neoplasms. PMID:21057533
11. LRP1B was hypermethylated in four gastric cancer cell lines, and low LRP1B mRNA expression was associated with high methylation levels in gastric cancer cell lines. PMID:20095042
12. results suggest that haplotypes in the gene LRP1B are significant/protective for successful aging without cognitive decline PMID:19367585
13. The LRP1B gene is a candidate tumor suppressor gene in urothelial cancer. PMID:12004004
14. LRP1B can function as a negative regulator of uPAR regeneration and cell migration. PMID:12194987
15. These findings reveal that low density lipoprotein receptor-related protein 1B is a novel binding partner of beta-amyloid precursor protein (APP) that functions to decrease APP processing to amyloid beta peptides. PMID:15126508
16. LRP1B modulates the catabolism of uPAR and PDGFR, affecting the migration of smooth muscle cells. PMID:15166012
17. Loss of LRP1B function in esophageal carcinogenesis most often occurs either by homozygous deletion or by transcriptional silencing through hypermethylation of its CpG island. PMID:15172977
18. Although mouse LRP1B expresses in the forms of both full-length receptor tail and an alternatively spliced form lacking a 33-amino acid insert, human LRP1B is expressed exclusively in the form of full-length receptor tail PMID:15963947
19. LRP1B functions as a receptor for Pseudomonas exotoxin. PMID:16095885
20. Frequent inactivation of LRP1B mainly occurs by means of epigenetic mechanisms in oral squamous cell carcinoma, which might play an important role in oral tumorigenesis. PMID:16918994
21. LRP1B has tumor suppression function that is mediated by proteolytic processing of the receptor resulting in intracellular domain release. PMID:17227771

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HGNC: 6693

UNIGENE: Hs.656461

KEGG: hsa:53353

STRING: 9606.ENSP00000374135

OMIM: 608766