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Recombinant Human Adhesion G protein-coupled receptor L3 (ADGRL3), partial

Recombinant Human Adhesion G protein-coupled receptor L3 (ADGRL3), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

LPHN3

Purity

>85% (SDS-PAGE)

Target Names

ADGRL3

Uniprot NO.

Q9HAR2

Alternative Names

ADGRL3; Adhesion G protein coupled receptor L3; Calcium independent alpha latrotoxin receptor 3; Calcium-independent alpha-latrotoxin receptor 3; CIRL 3; CIRL-3; CIRL3; CL3; cl3 latrotoxin receptor; KIAA0768; Latrophilin 3; Latrophilin homolog 3 (cow); Latrophilin homolog 3; Latrophilin-3; Latrophilin3; LEC 3; LEC3; Lectomedin 3; Lectomedin-3; Lectomedin3; lph3; LPHN 3; Lphn3; LPHN3_HUMAN

Species

Homo sapiens (Human)

Source

Baculovirus

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Gene References into Functions

An ultraconserved brain-specific enhancer within LPHN3 is associated with ADHD susceptibility. PMID:27692237
Associations between LPHN1 and LPHN3 polymorphisms and severity of bronchial hyper-responsiveness in asthmatics were conducted; however, no associations were found. PMID:27325752
Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5. PMID:26235030
LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD. PMID:25989180
Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed. PMID:25871512
genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. PMID:23245769
Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer. PMID:23317273
The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling. PMID:22575564
A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome. PMID:22832519
This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan. PMID:22105624
highly significant interaction between four SNPs and maternal stress during pregnancy and development of attention-deficit/hyperactivity disorder PMID:22486528
single-nucleotide polymorphisms harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD. PMID:21606926
This study demonistrated that LPHN3 and its ligand FLRT3 play an important role in glutamatergic synapse development. PMID:22405201
LPHN3, a new gene in which variants have recently been shown to be associated with adhd. PMID:21432600
These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder PMID:21040458
The mutational analysis of the entire coding region of LPHN3 in a cohort of 139 attention deficit hyperactivity disorder subjects and 52 controls, is reported. PMID:21184580