Recombinant Human Interleukin-27 subunit alpha (IL27)

1. Over-expression of IL-17 and IL-27 are involved in the pathogenesis of liver damage in children with human cytomegalovrius infection. PMID:30022757
2. Interleukin-27 differentially regulates the expression of seven novel microRNAs. PMID:29343703
3. Patients with tuberculous pleural effusion have an about 26-fold higher chance of being IL-27 test-positive compared to patients with malignant pleural effusion. [meta-analysis] PMID:29539604
4. there was a significant increase in the risk of Kawasaki disease with coronary arterial lesions in children with the rs17855750 (T>G), rs40837 (A>G), rs4740 (G>A), rs4905 (A>G), rs153109 (T>C), and rs26528 (A>G) Single-nucleotide Polymorphisms. PMID:29973303
5. our results showed that SNP rs153109 displayed significant associations with dilated cardiomyopathy in Chinese Han population, whereas no differences in genotype or allele frequencies were found between dilated cardiomyopathy patients and controls at SNP rs17855750. PMID:29754565
6. Human Immunodeficiency virus type-1 myeloid derived suppressor cells inhibit cytomegalovirus inflammation through IL-27 and B7-H4. PMID:28338007
7. IL-27 enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of p47(phox). PMID:28240310
8. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review) PMID:29218601
9. IL-27 rs153109 and rs17855750 Polymorphisms are associated with Risk and Response to Therapy in Acute Lymphoblastic Leukemia. PMID:28828696
10. IL-27 was down-regulated in the malignant Middle Cerebral Artery Infarction. PMID:28828208
11. IL-27 may be involved in the development of coronary artery lesions in acute Kawasaki disease. PMID:28108813
12. Hepatitis B virus infection can lead to overexpression of interleukin-27 gene in liver transplant patients. PMID:26925776
13. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer PMID:28508429
14. IL-27 signaling (IL-27 and its receptor) may be involved in the pathogenesis of HIV infection and immune reconstitution in HIV/AIDS patients who underwent HAART. IL-27 may exert effects through regulating Th1 / Th2 ratio. PMID:28521720
15. This study provides additional evidence that IL-27 may contribute to autoimmune processes in MS patients. PMID:28738904
16. this study shows that IL-27 regulates the adherence, proliferation, and migration of placenta-derived mesenchymal stromal cells and enhances their regulatory effects on Th1 and Th2 subset generations PMID:28612255
17. This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population PMID:27174010
18. Data point out to a broad set of activities shared by IL-27 and IFN-gamma, which are dependent on the common activation of the STAT1 pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation PMID:27683036
19. The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis PMID:25424605
20. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID:28756371
21. results indicate that elevated IL-27 strongly correlates with EOS and may provide additional diagnostic value along with PCT. PMID:27648693
22. serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome PMID:28167198
23. Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myocardial dysfunction compared with that in controls. PMID:27525353
24. IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine. PMID:26868086
25. IL-27 increased NLRP3 inflammasome activation in monocytes with enhanced release of IL-1 beta. PMID:29176764
26. this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease PMID:27221243
27. IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population PMID:26905929
28. IL-27 stimulation activated STAT1 and STAT3 in HeLa and T98G cells, suggesting that IL-27 engages the STAT1/3 pathway, which then leads to the upregulation of IL-6, IP-10, and MIG PMID:27617644
29. IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection. PMID:28874444
30. IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10. PMID:28300844
31. Significantly increased papillary thyroid carcinoma risk was also associated with rs17855750 GT and GT/GG genotypes. PMID:27929666
32. HIV and Tat inhibit LPS-induced IL-27 production in human macrophages via distinct mechanisms: Tat through the inhibition of cIAP-1-TRAF-6 and subsequent inhibition of PI3K and p38 MAPKs, whereas HIV through the inhibition of p38 MAPK activation. PMID:28698313
33. IL27 recapitulates IFN-gamma responses in hepatocellular carcinoma cells, but is inhibited by IL6-type cytokines. PMID:27939431
34. These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS-ATP stimulation. PMID:28377398
35. IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells PMID:27639718
36. the sIL-6R/p28 fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 to the IFN-lambda1 promoter via the p38 MAPK signaling pathway; results demonstrate the important role of sIL-6R/p28 FP in mediating virus-induced type III IFN production. PMID:27527594
37. These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID:28592538
38. IL30 regulates breast cancer cell viability, migration, and gene expression to promote breast cancer growth and progression and its impact on patient outcome. PMID:27550449
39. serum IL-27 levels were significantly higher in stage III EV71-infected hand, foot, and mouth disease patients with early cardiopulmonary failure and strong correlation with CRP levels; IL27p28 polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage PMID:27403033
40. these results suggest that IL-27 might predominantly play a protective role in the pathogenesis of psoriasis through abrogating Th17 differentiation. PMID:27939414
41. our data suggest a previously unrecognized role for IL-27 in regulating epithelial cell proliferation and antiviral host defense during the normal wound healing response. PMID:28132857
42. An association between the IL-27 single nucleotide polymorphism (SNP) rs153109 and Atrial Fibrillation was found in Chinese Han population. The G allele and GG genotype of rs153109 were associated with increased AF risk (odds ratio [OR]: 1.35, 95% confidence intervals [CI]=1.06-1.71, p=0.02 and OR: 1.66, 95% CI=1.03-2.65, p=0.03 in the recessive genetic model, respectively) PMID:28055231
43. Study demonstrated that levels of circulating serum IL-27 were elevated in rheumatoid arthritis (RA) patients and were positively correlated with RA disease activity. Moreover, these concentrations decreased after effective immunosuppressant treatment suggesting its involvement in the pathogenesis of RA. PMID:27869736
44. Data indicate that the genetic variant rs153109 in the 5' upstream region of interleukin 27 (IL-27) is significantly associated with ulcerative colitis (UC) in Chinese Han individuals. PMID:28069403
45. this study shows that the serum levels of IL-27 are lower in Iranian diabetes type I patients compared to the healthy individuals PMID:27611173
46. our findings showed a relationship between the IL-27 2905T/G genotype variant and the decreased susceptibility for developing cervical cancer. The IL-27 2905T/G genotype variant also modified the survival time in cervical cancer patients. PMID:26662568
47. an IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma PMID:27564404
48. Interleukin-27 rs 153109 Single Nucleotide Polymorphism is associated with responses to therapy in Hepatitis C. PMID:27221901
49. this study shows that IL-27 gene polymorphism is genetic risk factor for systemic lupus erythematosus in the Polish population, and that it predicts disease phenotype PMID:27059274
50. Data indicate that the CC genotype of interleukin 27 (IL-27) single nucleotide polymorphism rs153109 was significantly more prevalent in pre-eclampsia (PE) cases than controls. PMID:26971578

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HGNC: 19157

UNIGENE: Hs.528111

KEGG: hsa:246778

STRING: 9606.ENSP00000349365

OMIM: 608273