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Recombinant Human Interleukin-17 receptor E (IL17RE), partial

Recombinant Human Interleukin-17 receptor E (IL17RE), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

IL17RE

Purity

>85% (SDS-PAGE)

Target Names

IL17RE

Uniprot NO.

Q8NFR9

Alternative Names

IL17RE; UNQ3056/PRO9877; Interleukin-17 receptor E; IL-17 receptor E; IL-17RE

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Gene References into Functions

IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens. PMID:21993849

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Secreted.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Secreted.

Tissue Specificity

Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

Database Links

HGNC: 18439

UNIGENE: Hs.390823

KEGG: hsa:132014

STRING: 9606.ENSP00000295980

OMIM: 614995

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