Recombinant Human Interleukin-17 receptor D (IL17RD), partial

1. miR-193a-3p is downregulated in ulcerative colitis neoplasia, and its loss promotes carcinogenesis through upregulation of IL17RD. These findings provide novel insight into inflammation-driven colorectal cancer and could suggest new therapeutic targets in this high-risk population PMID:28600480
2. Low SEF expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer. PMID:26950413
3. Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT. PMID:28073170
4. IL17RD negatively regulates Toll-like receptor (TLR)-induced responses. PMID:25808990
5. Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms. PMID:25118304
6. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis. PMID:24681741
7. These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells. PMID:23770285
8. FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism. PMID:23643382
9. Downregulation of SEF mRNA is associated with prostate cancer. PMID:23169297
10. Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. PMID:23047677
11. This study establishes Sef as a feedback antagonist of proinflammatory cytokines and highlights its potential to regulate the crosstalk between proinflammatory cytokine receptors and receptor tyrosine kinases. PMID:22975329
12. The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 is increased. PMID:22335910
13. Findings indicate that Ras-induced nuclear accumulation of activated MEK1/2 was reliant on downregulation of the spatial regulator Sef. PMID:22298595
14. Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling PMID:12604616
15. human SEF is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis PMID:12807873
16. HSef acts as a spatial regulator for ERK signaling by targeting ERK to the cytoplasm. PMID:15239952
17. Sef binds to TAK1 and has a role in JNK activation and apoptosis PMID:15277532
18. Sef is downregulated in advanced prostate cancer and might facilitate an enhanced tumorigenic response to FGFs PMID:16474841
19. Sef inhibited FGF induced, but not RasG12V mediated, signal transduction. We propose that Sef interacted with Ras in the inhibition of Ras/MAPK signaling pathway. PMID:16859641
20. hSef isoforms can control signal specificity and subsequent cell fate by utilizing different mechanisms to modulate RTK signaling PMID:17035228
21. Inhibitory effect of hSef on cell proliferation combined with consistent downregulation in human carcinoma indicates a tumor suppressor-like role for Sef. PMID:17420726
22. Sef plays a positive role in the EGF/EGFR-mediated MAPK signaling pathway. PMID:18096367
23. IL 17RD protein is a part of the Interleukin-17 receptor signaling complex, therefore providing novel evidence for Interleukin-17 signaling through a heteromeric and/or homomeric receptor complex. PMID:19079364
24. CUG codon functions as a major translation initiation site in the alternatively spliced transcript variant hSef-b. PMID:14742870

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HGNC: 17616

UNIGENE: Hs.150725

KEGG: hsa:54756

STRING: 9606.ENSP00000296318

OMIM: 606807