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Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5), partial

Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5), partial

Baculovirus

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ITIH5

Purity

>85% (SDS-PAGE)

Target Names

ITIH5

Uniprot NO.

Q86UX2

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

17-942

Target Protein Sequence

SQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL MTEFSVKSTI ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM LIGDKVYQGE ITEREKKSGD RVKEKRNKTT EENGEKGTEI FRASAVIPSK DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ LSGRLSVDVN ILESAGIASL EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK PTVVQQARIA QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV TPDSIRDGKV YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL IVFLTDGKPT VGETHTLKIL NNTREAARGQ VCIFTIGIGN DVDFRLLEKL SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT PLLSDIRIDY PPSSVVQATK TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII LKTDVPVRPQ KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ SVRGAGTQPG PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID GQPGDILRLV SDHRDSGVTV NGELIGAPAP PNGHKKQRTY LRTITILINK PERSYLEITP SRVILDGGDR LVLPCNQSVV VGSWGLEVSV SANANVTVTI QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG LLGQFLNQDA RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May act as a tumor suppressor.

Gene References into Functions

ITIH5 may represent a novel modulator of TGF-beta superfamily signaling. PMID:28940371
Results provide evidence that ITIH5 triggers a reprogramming of breast cancer cells through global epigenetic changes effecting DAPK1. ITIH5 may represent an ECM modulator in epithelial breast tissue mediating suppression of tumor initiating cancer cell characteristics which are thought being responsible for the metastasis of breast cancer. PMID:28231808
Low ITIH5 expression is associated with liver metastasis in pancreatic cancer. PMID:28289921
This is the first study so far showing a putative tumor suppressive function of ITIH5 in cervical carcinogenesis. PMID:28059468
The current study describes a novel mechanism linking the TSG-6 transfer of the newly described HC5 to the HA-dependent control of cell phenotype. The interaction of HC5 with cell surface HA was essential for TGFbeta1-dependent differentiation of fibroblasts to myofibroblasts, highlighting its importance as a novel potential therapeutic target. PMID:27143355
ITIH5 may be a novel putative tumor suppressor gene in NSCLC with a potential molecular significance in the squamoid ADC subtype and further clinical impact for risk stratification of adenocarcinoma patients. PMID:26252352
Hence, we can strengthen the presumption that ITIH5 may constitute a novel regulatory molecule of the human skin that could play an important role in in fl ammation via its interaction with hyaluronic acid. PMID:25809190
ITIH5 expression is decreased in gastric cancer and that low expression of this protein is associated with poor clinical outcome. PMID:24913813
ITIH5 is a novel putative tumor suppressor gene in colon cancer with a potential impact in the CIMP-related pathway. PMID:25093535
Tumor-specific methylation of the three-gene panel (ITIH5, DKK3, and RASSF1A) might be a valuable biomarker for the early detection of breast cancer. PMID:23320751
provide evidence that down-regulation of ITIH5 by aberrant DNA hypermethylation may provoke invasive phenotypes in human bladder cancer PMID:24265292
ITIH5 gene expression is regulated both by obesity and by the region between visceral and subcutaneous adipose tissue. PMID:22616691
ITIH-5 is highly expressed in sc adipose tissue, increased in obesity, down regulated after weight loss, and associated with measures of body size and metabolism. PMID:21852814
expression is consistantly lost or strongly downregulated in invasive ductal carcinoma; proposed that loss of ITIH5 expression may be involved in breast cancer development PMID:14744536
Promoter methylation-mediated loss of ITIH5 expression is associated with unfavourable outcome in breast cancer patients. PMID:17653090
Both ITIH5 protein expression and ITIH5 promoter methylation may serve as prognostic biomarkers, thereby helping improve clinical patient outcome. PMID:18810445

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Subcellular Location

Secreted.

Protein Families

ITIH family

Tissue Specificity

Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested.

Database Links

HGNC: 21449

UNIGENE: Hs.498586

KEGG: hsa:80760

STRING: 9606.ENSP00000256861

OMIM: 609783

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