Recombinant Human Histone H2A type 1-A (H2AC1)

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

H2AC1

Uniprot NO.

Q96QV6

Alternative Names

HIST1H2AA; H2AFR; Histone H2A type 1-A; Histone H2A/r

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

2-131

Target Protein Sequence

SGRGKQGGK ARAKSKSRSS RAGLQFPVGR IHRLLRKGNY AERIGAGAPV YLAAVLEYLT AEILELAGNA SRDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK TESHHHKAQS K

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free

Buffer

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene References into Functions

Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation. PMID:28410146
Data indicate that formalin-fixed, paraffin-embedded (FFPE) tissue processing may result in persistent chemical modifications of histones, which correspond in mass shift of important post-translational modifications (PTMs). PMID:27941757

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Subcellular Location

Nucleus. Chromosome.

Protein Families

Histone H2A family

Database Links

HGNC: 18729

UNIGENE: Hs.406739

KEGG: hsa:221613

STRING: 9606.ENSP00000297012

OMIM: 613499

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