Recombinant Human Histone H2A-Bbd type 2/3 (H2AFB2)

Product Details

Purity
>85% (SDS-PAGE)
Target Names
H2AFB2;
Uniprot NO.
Species
Homo sapiens (Human)
Source
Yeast
Expression Region
1-115
Target Protein Sequence
MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR TAPVYLAAVI EYLTAKVLEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST LFNTTTISQV APGED
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
full length protein
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

 Customer Reviews

Target Background

Function(From Uniprot)
Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.
Gene References into Functions
  1. Changes in exon inclusion rates and increased presence of intronic sequences in mRNA products upon H2A.Bbd depletion. PMID:22795134

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Subcellular Location
Nucleus. Chromosome.
Protein Families
Histone H2A family
Tissue Specificity
Present in mature sperm.
Database Links

HGNC: 18298

UNIGENE: Hs.534498

KEGG: hsa:474381

STRING: 9606.ENSP00000358452

OMIM: 300445

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