Recombinant Human Histone H1.10 (H1-10)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

H1FX

Purity

>85% (SDS-PAGE)

Target Names

H1FX

Uniprot NO.

Q92522

Alternative Names

H1 histone family member X; H1FX; H1X; H1X_HUMAN; Histone H1x; MGC15959; MGC8350

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

2-213

Target Protein Sequence

SVELEEALP VTTAEGMAKK VTKAGGSAAL SPSKKRKNSK KKNQPGKYSQ LVVETIRRLG ERNGSSLAKI YTEAKKVPWF DQQNGRTYLK YSIKALVQND TLLQVKGTGA NGSFKLNRKK LEGGGERRGA PAAATAPAPT AHKAKKAAPG AAGSRRADKK PARGQKPEQR SHKKGAGAKK DKGGKAKKTA AAGGKKVKKA AKPSVPKVPK GRK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.

Gene References into Functions

comparison of primary aa sequence with other human H1 subtypes, and H1x from different species, generation of specific antibody, expression in different cell lines PMID:16006241
These results suggest that the differential localization of H1x provides a mechanism for a control of H1x activity by means of shuttling between nuclear subcompartments instead of a controlled turnover of the protein. PMID:17868027
study concludes that the high expression of histone H1x in neuroendocrine tumours is probably due to the abundance of this protein in the cells from which these tumours originate PMID:19108733

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Subcellular Location

Nucleus. Chromosome.

Protein Families

Histone H1/H5 family

Tissue Specificity

Expressed ubiquitously.

Database Links

HGNC: 4722

UNIGENE: Hs.75307

KEGG: hsa:8971

STRING: 9606.ENSP00000329662