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Recombinant Human HLA class II histocompatibility antigen, DO beta chain (HLA-DOB), partial

Recombinant Human HLA class II histocompatibility antigen, DO beta chain (HLA-DOB), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

HLA-DOB

Uniprot NO.

P13765

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Gene References into Functions

results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence PMID:28813660
HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9. PMID:23400868
HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID:12439622
A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing. PMID:15730525

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Subcellular Location

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Protein Families

MHC class II family

Database Links

HGNC: 4937

UNIGENE: Hs.1802

KEGG: hsa:3112

STRING: 9606.ENSP00000390020

OMIM: 142920

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