Recombinant Human Guanine nucleotide-binding protein subunit alpha-13 (GNA13)

1. High expression of GNA13 is associated with hepatocellular carcinoma. PMID:27883022
2. The ability of enhanced GNA13 signaling to suppress KLK gene expression appears at least in part due to the ability of enhanced GNA13 signaling to negatively impact Rho/ROCK-signaling. PMID:27424208
3. the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis. PMID:28126591
4. The protein profile indicates attenuation of "GNA13-ERK signaling" in schizophrenia brain. In particular, EIF4G2 and CYFIP1, which are located downstream of the GNA13-ERK network, were decreased, suggesting that the attenuation of this signal network may cause impairment of axon formation and synapse plasticity in the brain of schizophrenia patients. PMID:28214564
5. Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA GTP-binding protein (RhoA) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL). PMID:26616858
6. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) PMID:28432124
7. Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer. PMID:26735177
8. Knockdown DDR1 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen. PMID:26589794
9. RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13. PMID:26323264
10. Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets PMID:26292217
11. GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR-31. PMID:25889182
12. Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation. PMID:26100877
13. Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of colorectal cancer PMID:25193986
14. These results place Blk upstream of the p190RhoGAP-RhoA pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12-triggered invasion. PMID:25025568
15. findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma PMID:25274307
16. Findings indicate lysophosphatidic acid (LPA)-lysophosphatidic acid receptor-Galpha13 signaling node as a therapeutic target for pancreatic cancer treatment and control. PMID:23508014
17. Mutation in the Galpha13 gene is associated with diffuse large B-cell lymphoma. PMID:23699601
18. Itk enhances Galpha13 mediated activation of serum response factor (SRF) transcriptional activity dependent on its ability to interact with Galpha13, but its kinase activity is not required to enhance SRF activity. PMID:23454662
19. GNA13 is an important mediator of prostate cancer cell invasion, and miR-182 and miR-200 family members regulate its expression post-transcriptionally PMID:23329838
20. Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. PMID:22661716
21. signaling-selective inhibition of the CXCR4-Galpha(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells. PMID:21934106
22. alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened PMID:21757753
23. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase PMID:21592972
24. Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions. PMID:21212405
25. A new role is described for Galpha13 as a mediator of chemokine receptor CXCR4 endosomal trafficking in human T cells. PMID:21148034
26. Galpha(12) binds to p120(ctn) and modulates its phosphorylation status through a Rho-independent mechanism. Galpha(12) emerges as an important regulator of p120(ctn) function PMID:20974127
27. Galpha12/13 upregulate matrix metalloproteinase-2 via p53 promoting human breast cell invasion. PMID:20044778
28. G(alpha)(12) and G(alpha)13) exert a complex pattern of nonredundant effects in small cell lung cancer cells PMID:20160064
29. This review gives an overview of Galpha12/13 signaling of G protein-coupled receptors with a focus on RhoGTPase nucleotide exchange factor (RhoGEF) proteins as the immediate mediators of G12/13 activation. PMID:19226283
30. The studies highlighted in this review provide compelling evidence that Galpha12 and Galpha13 play pivotal roles in many aspects of cancer invasion and metastasis. PMID:19422395
31. study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA PMID:20075254
32. Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin PMID:11976333
33. Galpha13 is not associated with lipid rafts PMID:12117999
34. Galpha13 can induce ppET-1 gene expression through a JNK-mediated pathway. PMID:12135322
35. co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium PMID:12297512
36. These results suggest that protein kinase A blocks Rho activation by phosphorylation of Galpha(13) Thr(203). PMID:12399457
37. Selective activation of Galpha(12) and Galpha(13) by thrombin and LPA, respectively, is determined by the N-terminal short sequences of alpha subunits. PMID:12594220
38. Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. PMID:15735747
39. Galpha13-induced VASP phosphorylation that involves activation of RhoA and MEKK1, phosphorylation and degradation of IkappaB, release of PKA catalytic subunit from the complex with IkappaB and NF-kappaB, and subsequent phosphorylation of VASP PMID:16046415
40. analysis of the molecular mechanism of how the human TXA2 receptor interacts with G alpha 13 to activate intracellular signaling PMID:16212421
41. Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration. PMID:16601072
42. Results identify the G12 family proteins Galpha12 and 13 as important regulators of prostate cancer invasion and suggest that these proteins may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality. PMID:16787920
43. Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4 PMID:17056591
44. Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs. PMID:17449226
45. analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway PMID:17493936
46. G alpha(12/13) regulate basal p53 levels via mdm4, which constitutes a cell signaling pathway distinct from p53 phosphorylations elicited by genotoxic stress. PMID:17510313
47. role in regulating ASK1 expression levels PMID:17595347
48. provides first examination of Galpha12 and Galpha13 in the human heart, demonstrating selective activation of human atrial Galpha12 and Galpha13 by endothelin and angiotensin receptors, respectively PMID:17878759
49. A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. PMID:18320579
50. AC7 is a specific downstream effector of the G(12/13) pathway PMID:18541530

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HGNC: 4381

UNIGENE: Hs.515018

KEGG: hsa:10672

STRING: 9606.ENSP00000400717

OMIM: 604406