Recombinant Human Growth/differentiation factor 3 (GDF3)

1. the 4 of the 5 variants in [i]GDF3[/i] gene contribute different pathogenicity in congenital scoliosis, which may provide molecular evidence for clinical genetic testing. PMID:29735971
2. OCT4 plays a role as a transcriptional activator for GDF3 transcription in pluripotent human embryonic carcinoma NCCIT cells and contributes to the understanding of the molecular networks of stem cell regulators in germ cell-derived pluripotency and tumorigenesis. PMID:27803451
3. The results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs. PMID:25372014
4. first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells PMID:22963770
5. GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues. PMID:22488170
6. the conditioned medium from CHO-GDF3 could reduce PC12 cell growth and induce cell differentiation PMID:21805089
7. Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells. PMID:22305102
8. Mutation of GDF3 causes ocular and skeletal anomalies. PMID:19864492
9. Present data suggested that GDF3 might play important roles in the central nervous system (CNS), especially in cerebral cortex, hippocampus and cerebellum, and it shed new light on further research of GDF3 in the central nervous system. PMID:16126341
10. GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types. PMID:16339188
11. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID:18480259
12. GDF3 is either a bi-functional TGF-beta ligand, or, more likely, that it is a BMP inhibitor that can artificially activate Nodal signaling under non-physiological conditions. PMID:18823971
13. GDF3 positivity is helpful in the diagnosis of yolk sac tumor PMID:19396148

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HGNC: 4218

UNIGENE: Hs.86232

KEGG: hsa:9573

STRING: 9606.ENSP00000331745

OMIM: 606522