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Recombinant Human Glycoprotein hormone alpha-2 (GPHA2)

Recombinant Human Glycoprotein hormone alpha-2 (GPHA2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

GPHA2

Purity

>85% (SDS-PAGE)

Target Names

GPHA2

Uniprot NO.

Q96T91

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

24-129

Target Protein Sequence

QEAVIPG CHLHPFNVTV RSDRQGTCQG SHVAQACVGH CESSAFPSRY SVLVASGYRH NITSVSQCCT ISGLKKVKVQ LQCVGSRREE LEIFTARACQ CDMCRLSRY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.

Gene References into Functions

expressed in osteoblasts and osteoclasts PMID:26018249
identification and characterization of GPA2 genes PMID:12089349
GPA2, and another beta-subunit, GPB5, in human, are capable of forming heterodimers to activate TSH receptors. PMID:15890769
cloning and functional analysis of the promoter of the thyrostimulin A2 subunit PMID:16376481
Sudy illustrated that GPA2 is positively regulated by isl-1, suggesting that this protein associates with endocrine systems including the pituitary and pancreas. PMID:17363077