Recombinant Human Fibroblast growth factor 11 (FGF11)

1. Endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs). PMID:29852165
2. FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents PMID:28097375
3. Exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC). PMID:27538493
4. these results suggest a cross-regulation between HIF-1alpha and FGF11, through which hypoxia-induced FGF11 reinforces hypoxia responses by enhancing the stability of HIF-1alpha. PMID:28027390
5. Study found that FGF11 expression can be induced through HIF-1 binding sites in its promoter region suggesting that FGF11 acts as a novel modulator of hypoxia-induced pathological processes such as tumor progression. PMID:26323829
6. these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-->miRNA-541-->AR-->MMP9 signaling. PMID:25135278

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HGNC: 3667

UNIGENE: Hs.655193

KEGG: hsa:2256

STRING: 9606.ENSP00000293829

OMIM: 601514