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Recombinant Human Fc receptor-like protein 1 (FCRL1), partial

Recombinant Human Fc receptor-like protein 1 (FCRL1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

FCRL1

Purity

>85% (SDS-PAGE)

Target Names

FCRL1

Uniprot NO.

Q96LA6

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.

Gene References into Functions

FCRL1 gene expression down-regulates in both Hashimoto and Graves disease patients compared to normal subjects. PMID:25738996
Data show the Differences in high resolution melting analysis in promoters of tumor markers neuronal membrane glycoprotein M6-B, melanoma antigen family A12 and immunoglobulin superfamily Fc receptor indicated invasiveness of hepatocellular carcinoma. PMID:23950870
Expression level of FCRL1 gene in peripheral blood B-lymphocytes is significantly higher in patients with autoimmune diseases. PMID:22888639
FcRH1 thus has the potential to serve as an activating coreceptor on B cells. PMID:15479727
Down-regulation of FCRL1 is associated with acute lymphoblastic leukemia. PMID:18802695

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus mem

Database Links

HGNC: 18509

UNIGENE: Hs.656112

KEGG: hsa:115350

STRING: 9606.ENSP00000357158

OMIM: 606508

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