Recombinant Human Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

1. p19(INK4d) plays an active role during human tooth development along with MSX1 and MSX2 PMID:28933666
2. We unexpectedly found that p19INK4d plays an important role in human terminal erythropoiesis PMID:27879259
3. p19(INK4D) is one of the key mediators of miR-125b activity during the onset of megakaryocyte polyploidization. PMID:27763644
4. p19 may play an important role in the ototoxic effects of cisplatin and is probably involved in the pathogenesis of hearing loss. PMID:26722409
5. MiR-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 expression. PMID:26019450
6. Data indicate that upon oxidative DNA damage, cyclin-dependent kinase inhibitor p19INK4d strongly binds to and relaxes chromatin. PMID:25204969
7. CDKN2D repression by PML/RARalpha disrupts both cell proliferation and differentiation in the pathogenesis of acute promyelocytic leukemia. PMID:25275592
8. p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas. PMID:25104850
9. CDKN2D-WDFY2 fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas. PMID:24675677
10. Mutations in CDKN2D is associated with sporadic parathyroid adenoma. PMID:24127162
11. P19(INK4d) expression is a poor prognostic factor in ovarian cancer patients. PMID:24022213
12. PTB plays as a negative regulator in H1299 cell proliferation at least by inducing p19(Ink4d) expression at transcriptional and post-transcriptional levels. PMID:23536791
13. Up-regulation of CDKN2D during in-vitro passages of human amniotic fluid-derived mesenchymal stromal cells may indicate the begging of early senescence process in a p53-independent mechanism. PMID:22747700
14. E2F1 is involved in the induction of p19INK4d following UV irradiation PMID:22476863
15. CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response to ensure cell survival. PMID:22558186
16. expression of p19INK4D may be an effective predictor of clinical behavior in hepatocellular carcinoma, and therefore, a new prognostic marker PMID:21901251
17. p19INK4d is transcriptionally regulated by E2F1 through two response elements present in the p19INK4d promoter. PMID:21765927
18. protein folding and stability PMID:11786024
19. The human p19(INK4d) gene is under the control of TATA-less promoter and the Sp1 binding site is involved in the transcription. PMID:12062451
20. Deletions in the CDKN2D locus and hypermethylation in the CDKN2D promoter region plays a role in ovarian granulosa cell tumorogenesis. PMID:12203782
21. p19(INK4d) in addition to p21(WAF1/Cip1) is an important molecular target of HDAC inhibitors inducing growth arrest PMID:15107822
22. In addition to its role as cell cycle inhibitor, p19INK4d is involved in maintenance of DNA integrity and, therefore, would contribute to cancer prevention. PMID:15750620
23. Data suggest that the graded stability and the facile unfolding of repeats 1 and 2 is a prerequisite for the down-regulation of the inhibitory activity of p19(INK4d) during the cell-cycle. PMID:17804013
24. The study shows that mimicking the phosphorylation site of p19INK4d by a glutamate substitution at position 76 dramatically decreases the stability of the native but not an intermediate state. PMID:19063602

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HGNC: 1790

UNIGENE: Hs.435051

KEGG: hsa:1032

STRING: 9606.ENSP00000337056

OMIM: 600927