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Recombinant Human Collagen alpha-1 (XXII) chain (COL22A1), partial

Recombinant Human Collagen alpha-1 (XXII) chain (COL22A1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

COL22A1

Purity

>85% (SDS-PAGE)

Target Names

COL22A1

Uniprot NO.

Q8NFW1

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

28-1626

Target Protein Sequence

QRA GCKSVHYDLV FLLDTSSSVG KEDFEKVRQW VANLVDTFEV GPDRTRVGVV RYSDRPTTAF ELGLFGSQEE VKAAARRLAY HGGNTNTGDA LRYITARSFS PHAGGRPRDR AYKQVAILLT DGRSQDLVLD AAAAAHRAGI RIFAVGVGEA LKEELEEIAS EPKSAHVFHV SDFNAIDKIR GKLRRRLCEN VLCPSVRVEG DRFKHTNGGT KEITGFDLMD LFSVKEILGK RENGAQSSYV RMGSFPVVQS TEDVFPQGLP DEYAFVTTFR FRKTSRKEDW YIWQVIDQYS IPQVSIRLDG ENKAVEYNAV GAMKDAVRVV FRGSRVNDLF DRDWHKMALS IQAQNVSLHI DCALVQTLPI EERENIDIQG KTVIGKRLYD SVPIDFDLQR IVIYCDSRHA ELETCCDIPS GPCQVTVVTE PPPPPPPQRP PTPGSEQIGF LKTINCSCPA GEKGEMGVAG PMGLPGPKGD IGAIGPVGAP GPKGEKGDVG IGPFGQGEKG EKGSLGLPGP PGRDGSKGMR GEPGELGEPG LPGEVGMRGP QGPPGLPGPP GRVGAPGLQG ERGEKGTRGE KGERGLDGFP GKPGDTGQQG RPGPSGVAGP QGEKGDVGPA GPPGVPGSVV QQEGLKGEQG APGPRGHQGA PGPPGARGPI GPEGRDGPPG LQGLRGKKGD MGPPGIPGLL GLQGPPGPPG VPGPPGPGGS PGLPGEIGFP GKPGPPGPTG PPGKDGPNGP PGPPGTKGEP GERGEDGLPG KPGLRGEIGE QGLAGRPGEK GEAGLPGAPG FPGVRGEKGD QGEKGELGLP GLKGDRGEKG EAGPAGPPGL PGTTSLFTPH PRMPGEQGPK GEKGDPGLPG EPGLQGRPGE LGPQGPTGPP GAKGQEGAHG APGAAGNPGA PGHVGAPGPS GPPGSVGAPG LRGTPGKDGE RGEKGAAGEE GSPGPVGPRG DPGAPGLPGP PGKGKDGEPG LRGSPGLPGP LGTKAACGKV RGSENCALGG QCVKGDRGAP GIPGSPGSRG DPGIGVAGPP GPSGPPGDKG SPGSRGLPGF PGPQGPAGRD GAPGNPGERG PPGKPGLSSL LSPGDINLLA KDVCNDCPPG PPGLPGLPGF KGDKGVPGKP GREGTEGKKG EAGPPGLPGP PGIAGPQGSQ GERGADGEVG QKGDQGHPGV PGFMGPPGNP GPPGADGIAG AAGPPGIQGS PGKEGPPGPQ GPSGLPGIPG EEGKEGRDGK PGPPGEPGKA GEPGLPGPEG ARGPPGFKGH TGDSGAPGPR GESGAMGLPG QEGLPGKDGD TGPTGPQGPQ GPRGPPGKNG SPGSPGEPGP SGTPGQKGSK GENGSPGLPG FLGPRGPPGE PGEKGVPGKE GVPGKPGEPG FKGERGDPGI KGDKGPPGGK GQPGDPGIPG HKGHTGLMGP QGLPGENGPV GPPGPPGQPG FPGLRGESPS METLRRLIQE ELGKQLETRL AYLLAQMPPA YMKSSQGRPG PPGPPGKDGL PGRAGPMGEP GRPGQGGLEG PSGPIGPKGE RGAKGDPGAP GVGLRGEMGP PGIPGQPGEP GYAKDGLPGI PGPQGETGPA GHPGLPGPPG PPGQCDPSQC AYFASLAARP GNVKGP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts.

Gene References into Functions

Collage XXII interacts with collagen-binding integrins via the protein motifs GLQGER and GFKGER. PMID:24428702
association between serum creatinine level and polymorphisms in the collagen type XXII alpha 1 (COL22A1) gene, on chromosome 8, and in the synaptotagmin-1 (SYT1) gene, on chromosome 12 PMID:20222955
collagen XXII is the first specific extracellular matrix protein present only at tissue junctions PMID:15016833

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Subcellular Location

Secreted, extracellular space, extracellular matrix. Cytoplasm.

Protein Families

Fibril-associated collagens with interrupted helices (FACIT) family

Tissue Specificity

Restrictive expression is observed at tissue junctions such as the myotendinous junction in skeletal and heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair follicle and the dermis in the skin. It is deposi

Database Links

HGNC: 22989

UNIGENE: Hs.117169

KEGG: hsa:169044

STRING: 9606.ENSP00000303153

OMIM: 610026

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