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Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes (CDON), partial

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes (CDON), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CDON

Purity

>85% (SDS-PAGE)

Target Names

CDON

Uniprot NO.

Q4KMG0

Alternative Names

CDO; Cdon; CDON_HUMAN; Cell adhesion molecule-related/down-regulated by oncogenes

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Gene References into Functions

We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID:26529631
CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID:25369201
These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID:25313246
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID:24740842
Mutations in the CDON cause holoprosencephaly. (Review) PMID:22326621
We found that CDON is overexpressed in prostate cancer PMID:21849809
CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID:21802063
Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID:20519495
CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID:12720294
CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID:12634428
Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID:12620190