Recombinant Human Caspase recruitment domain-containing protein 10 (CARD10), partial

1. The results suggest that the involvement of CARMA3 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6. PMID:28717989
2. Card10 polymorphisms may not be linked with psoriasis vulgaris in the southern Han Chinese population. PMID:28301668
3. Data indicate no association between caspase recruitment domain family, member 10 protein (CARD10) polymorphism rs6000782 and type 1 autoimmune hepatitis (AIH) in a Japanese population. PMID:26652023
4. Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus. PMID:26526492
5. miR-24 inhibited cell proliferation, invasion and epithelial to mesenchymal transition in bladder cancer cells by downregulation of CARMA3 PMID:26252200
6. The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins. PMID:25541973
7. A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified. PMID:25906011
8. CARMA3 regulates the ovarian cancer cell proliferation, cell cycle progression, and chemoresistance. PMID:24833094
9. CARMA3 is overexpressed in pancreatic cancer and regulates malignant cell growth, invasion, and NF-kappaB signaling, which was dependent on its association with Bcl10. PMID:24633921
10. CARMA3 is overexpressed in bladder cancer and regulates malignant cell growth and NF-kappaB signaling. PMID:24443255
11. Genetic variation within PARP1 and CARD10 was associated with rate of hippocampal neurodegeneration in APOE e3/e3 patients. PMID:23608917
12. CARD10 may be involved in hepatic carcinogenesis associated with hepatitis C in Egyptian patients. PMID:24018495
13. overexpression of CARMA3 in human glioma and its correlation with tumor grade. PMID:23893382
14. Data show that CARMA3 may serve as a novel and prognostic marker for renal cell carcinoma (RCC) and play a role during the development and progression of the disease. PMID:23771851
15. CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factor-kappaB signaling. PMID:23708960
16. this study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-kappaB mediated upregulation of cyclin D1. PMID:22884800
17. The overexpression of CARMA3 was significantly correlated with TNM stage (P = 0.022) and tumor status (P = 0.013). PMID:22615840
18. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID:21307088
19. Data show that CARMA3 and Bcl10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion. PMID:21406399
20. CARMA1 and CARMA3 bind to Ikappa kinase gamma-NFkappaB in B and T lymphocytes PMID:15184390
21. Protein kinase C-CARMA3 signaling axis plays an essential role in lysophosphatidic acid-induced ovarian cancer cell in vitro invasion. PMID:17724468
22. results further define the molecular mechanisms that control activation of NF-kappaB and reveal a function for A20 in the regulation of CARMA and BCL10 activity in lymphoid and non-lymphoid cells PMID:18349075
23. Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation. PMID:18757306

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HGNC: 16422

UNIGENE: Hs.57973

KEGG: hsa:29775

STRING: 9606.ENSP00000251973

OMIM: 607209