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Recombinant Human Calcium-activated chloride channel regulator 2 (CLCA2), partial

Recombinant Human Calcium-activated chloride channel regulator 2 (CLCA2), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CLCA2

Purity

>85% (SDS-PAGE)

Target Names

CLCA2

Uniprot NO.

Q9UQC9

Alternative Names

CLCA2; CACC3Calcium-activated chloride channel regulator 2; EC 3.4.-.-; Calcium-activated chloride channel family member 2; hCLCA2; Calcium-activated chloride channel protein 3; CaCC-3; hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2; 109 kDa form; Calcium-activated chloride channel regulator 2; 35 kDa form]

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.

Gene References into Functions

we found by calcium imaging that CLCA2 moderately enhanced intracellular-store release but dramatically increased store-operated entry of calcium upon cytosolic depletion PMID:29758025
CLCA2 links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation. PMID:26930581
CLCA2 expression is higher in squamous cell carcinoma of the lung compared with adenocarcinoma. PMID:25548429
Variants in CLCA2 were associated with an ileal involvement phenotype of Crohn's disease. PMID:25557950
These results strongly suggest that CLCA2 is involved in the p53 tumor suppressor network and has a significant effect on cell migration and invasion. PMID:22990203
hCLCA2 is required for epithelial differentiation, and its loss during tumor progression contributes to metastasis. PMID:21909135
the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer PMID:22431922
Expression of hSK4 as well as hCACC-2 and hCACC-3 but not hCACC-1 was demonstrated by reverse transcriptase PCR on native nasal tissues. PMID:12612194
immunohistochemistry clearly demonstrated colocalisation between hCLCA2 and integrin beta4 PMID:15707651
human CLCA2 protein and mRNA expression are elevated during epithelial stratification, suggesting that this protein plays a role in the growth of multi-layered corneal epithelia during both natural development and tissue cultivation. PMID:16158324
Mostly extracellular with only a single transmembrane segment, unlikely to form a channel. PMID:16873362
hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation. PMID:19654313

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.

Protein Families

CLCR family

Tissue Specificity

Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenita

Database Links

HGNC: 2016

UNIGENE: Hs.241551

KEGG: hsa:9635

STRING: 9606.ENSP00000359596

OMIM: 604003

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