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Recombinant Human Calcineurin subunit B type 1 (PPP3R1)

Recombinant Human Calcineurin subunit B type 1 (PPP3R1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PPP3R1

Uniprot NO.

P63098

Alternative Names

alpha isoform (calcineurin B; type I); calcineurin B; type I (19kDa); Calcineurin subunit B type 1; CALNB1; CANB1_HUMAN; Cna2; CNB; CNB1; OTTHUMP00000201960; OTTHUMP00000201961; Ppp3r1; PPP3R1 protein phosphatase 3 (formerly 2B); regulatory subunit B; alpha isoform; protein phosphatase3 (formerly2B); regulatory subunit B; alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B); regulatory subunit B; 19kDa; alpha isoform (calcineurin B; type I); Protein phosphatase 3 (formerly 2B); regulatory subunit B (19kD); alpha isoform (calcineurin B; type I); Protein phosphatase 3 regulatory subunit B alpha; Protein phosphatase 3 regulatory subunit B alpha isoform 1

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

2-170

Target Protein Sequence

GNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Gene References into Functions

expression of PPP3R1 decreased respectively in psoriatic lesions and HaCaT cells. PMID:29181737
The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels. PMID:28827117
we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 PMID:27090571
CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 signaling through TRAF3 and TRAF6, in response to various agonists. PMID:26471241
Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B. PMID:24246042
Further evidence that specific variations in MAPT (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease PMID:23727081
Expression level of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in studied subgroups of patients. PMID:23888774
Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. PMID:22814600
These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity. PMID:22197822
immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection PMID:21722668
CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells. PMID:21910968
CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. PMID:21256111
these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation. PMID:17038582
Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. PMID:17237284
IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women. PMID:17761791
No significant differences in calcineurin b expression was observed between patients with schizophrenia and normal controls PMID:18343007
Overexpression of calcineurin B subunit enhances the oncogenic potential of HEK293 cells PMID:18422742
Study found that although calcineurin/NFAT signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages. PMID:18818667
CNB gene 5I/5D polymorphism is associated with the risk of left ventricular hypertrophy and physical performance of athletes. PMID:18825932