Purity
Greater than 85% as determined by SDS-PAGE.
Alternative Names
Histone lysine acetyltransferase CREBBP;Protein-lysine acetyltransferase CREBBP
Species
Homo sapiens (Human)
Expression Region
1081-1197aa
Target Protein Sequence
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Tag Info
N-terminal GST-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage Condition
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
Amino acids 1081-1197 form the expressed segment for recombinant Human CREBBP. This CREBBP protein is theoretically predicted to have a molecular weight of 40.7 kDa. This CREBBP recombinant protein is manufactured in e.coli. The CREBBP gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant CREBBP protein during the following stages.
The human CREB-binding protein (CREBBP) is a versatile transcriptional coactivator that plays a pivotal role in gene regulation. CREBBP is involved in modulating various cellular processes by interacting with a wide range of transcription factors and nuclear receptors. It serves as a histone acetyltransferase, facilitating chromatin remodeling and promoting transcriptional activation. CREBBP is essential for embryonic development and has implications for cell growth, differentiation, and apoptosis. Dysregulation or mutations in CREBBP are associated with several genetic disorders, including Rubinstein-Taybi syndrome. Ongoing research focuses on unraveling the molecular mechanisms of CREBBP function, its involvement in disease pathways, and potential therapeutic interventions targeting its activity.
