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Recombinant Human Autophagy-related protein 101 (ATG101)

Recombinant Human Autophagy-related protein 101 (ATG101)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ATG101

Purity

>85% (SDS-PAGE)

Target Names

ATG101

Uniprot NO.

Q9BSB4

Alternative Names

ATG101; Atg13-interacting protein; ATGA1_HUMAN; Autophagy-related protein 101; C12orf44; Chromosome 12 open reading frame 44; FLJ11773; OTTHUMP00000241687; OTTHUMP00000241688; OTTHUMP00000241689

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-218

Target Protein Sequence

MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV GTQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE KIINIVEVMN RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITDAL GTSVTTTMRR LIKDTLAL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.

Gene References into Functions

Structure of the human Atg13-Atg101 HORMA heterodimer in the ULK1 complex that controls autophagy has been described. PMID:26299944
Data indicate mitogen lacritin stimulates FOXO3-ATG101 and FOXO1-ATG7 autophagic coupling and restores metabolic homeostasis. PMID:23640897
The identification of the novel protein, Atg101, and the validation of Atg13 and Atg101 as ULK1-interacting proteins, suggests an Atg1 complex is involved in the induction of macroautophagy in mammalian cells. PMID:19287211
These data suggest that Atg101 is a novel Atg protein that functions together with ULK, Atg13 and FIP200. PMID:19597335