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Recombinant Human Activin receptor type-1C (ACVR1C), partial

Recombinant Human Activin receptor type-1C (ACVR1C), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ACVR1C

Purity

>85% (SDS-PAGE)

Target Names

ACVR1C

Uniprot NO.

Q8NER5

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Gene References into Functions

reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin PMID:26836979
Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. PMID:26406402
Alk7 is expressed in male germ cells and Sertoli cells. PMID:26289399
ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. PMID:23793810
Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. PMID:23765385
reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. PMID:22086737
These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. PMID:21356369
cDNA cloning, expression studies and chromosome mapping PMID:12063393
ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated PMID:12606401
ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID:15107418
the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest PMID:15150278
AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID:15196700
ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap. PMID:16603637
GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID:18480259
The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID:18784254
One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. PMID:18951876
Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. PMID:19275893

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Tissue Specificity

Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.

Database Links

HGNC: 18123

UNIGENE: Hs.562901

KEGG: hsa:130399

STRING: 9606.ENSP00000243349

OMIM: 608981

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