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Recombinant Human ATP-binding cassette sub-family B member 9 (ABCB9), partial

Recombinant Human ATP-binding cassette sub-family B member 9 (ABCB9), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ABCB9

Purity

>85% (SDS-PAGE)

Target Names

ABCB9

Uniprot NO.

Q9NP78

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.

Gene References into Functions

The structure of the unique domain of TAPL, is reported. PMID:24013930
LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles. PMID:22641697
These results suggest that TAPL may be localized to the microdomains (lipid rafts) of lysosomal membranes enriched in cholesterol. PMID:21212514
By dissecting ABCB9, distinct functions were assigned to the core complex and the extra N-terminal transmembrane domain. PMID:20377823
is part of the peptide-loading complex in the classic route of antigen processing via major histocompatibility complex class I molecules PMID:15863492
These findings suggest that the transport activity of hTAPL is important for conferring high valinomycin-sensitive phenotype to yeast. PMID:16554024
the TAPL-specific translocation of peptides into isolated lysosomes strictly requires ATP hydrolysis PMID:17977821
The ATP-binding of TAPL required Mg(2+), and was observed at neutral pH. Chemical cross-linking experiments suggested that TAPL forms a homodimer in the membrane and under the solubilized conditions. PMID:18175933
analysis of lipid activation of the lysosomal transport complex ABCB9 PMID:18434309
These results suggest that the sorting signal for lysosomes is present within the amino-terminal transmembrane domain (Met(1)-Arg(141)) of the TAPL molecule. PMID:18952056

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Subcellular Location

Lysosome membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily

Tissue Specificity

Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.

Database Links

HGNC: 50

UNIGENE: Hs.511951

KEGG: hsa:23457

STRING: 9606.ENSP00000280560

OMIM: 605453

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