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Recombinant Horse Interleukin-23 subunit alpha (IL23A)

Recombinant Horse Interleukin-23 subunit alpha (IL23A)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

IL23A

Purity

>85% (SDS-PAGE)

Target Names

IL23A

Uniprot NO.

Q64FU1

Alternative Names

IL23AInterleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19

Species

Equus caballus (Horse)

Source

Yeast

Expression Region

22-192

Target Protein Sequence

RAVPGGSSP AWAQCQQLSQ KLCTLAWSAH PPMGHVDLPR EEGDAETTND VPHIQCEDGC DPEGLRDNSQ PCLQRIHQGL VFYEKLLGSD IFTGEPSLLP NGPVDQLHAS LLGLRQLLQP EGHHWETEQI PSPSPSQPWQ RLLLRPKILR SLQAFVAVAA RVFAHGAATL TP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene References into Functions

cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells PMID:19775756
This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction. PMID:18052742
The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses. PMID:19795943

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Subcellular Location

Secreted.

Protein Families

IL-6 superfamily

Database Links

UNIGENE: Eca.3086

KEGG: ecb:100034230

STRING: 9796.ENSECAP00000019716

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