Recombinant Horse Chromogranin-A (CHGA)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

CHGA

Purity

>85% (SDS-PAGE)

Target Names

CHGA

Uniprot NO.

Q9XS63

Species

Equus caballus (Horse)

Source

Yeast

Expression Region

19-448

Target Protein Sequence

LP VNSPMDTGDT EVMKCIVEVI SDTLSKPSPV PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER APQQKHSRLE DELAEVLEKQ NHQAELKEVT EEALSEDAAE ARGDSKEVEE NGEDADGARP QAALEPEQES RVEDAQAPGE EKEAINTHSP TRLPSQKHPD PQAEGDSDSP SQGLVDREKG LGAERGQQAK REEEEDEAGE KADAEEEGPT AAFNPHPSLS YKIRKGESWS EALVVDGARK TGAEEAQPPE GQGEREHSRQ EEEEEEETAG ASRGLFRGGK SRELEQEKEQ ERLSKEWEDA KRWSKMDQLA KELTAEKRLE GEDEEEDDPD RSMKLSFRAR AYGFRGPGLQ LRRGWRPSSR EDSIEAGLPP PVRGYPEEKK EEEGSANRRP EDQELESLSA IEAELEKVAH QLQALRRG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Strongly inhibits glucose induced insulin release from the pancreas.; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Subcellular Location

[Serpinin]: Secreted. Cytoplasmic vesicle, secretory vesicle.; Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted.

Protein Families

Chromogranin/secretogranin protein family

Tissue Specificity

Highly expressed in adrenal medulla and pituitary gland. Weaker expression detected in cerebrum, cerebellum, spinal cord, liver, thyroid gland, striated muscle, lung, spleen, kidney, parotid gland, and sublingual gland.

Database Links

UNIGENE: Eca.13001

KEGG: ecb:100033828

STRING: 9796.ENSECAP00000016838

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