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Recombinant Guinea pig Nitric oxide synthase, inducible (NOS2), partial

Recombinant Guinea pig Nitric oxide synthase, inducible (NOS2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

NOS2

Uniprot NO.

O54705

Alternative Names

NOS2; NOSNitric oxide synthase; inducible; EC 1.14.13.39; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2

Species

Cavia porcellus (Guinea pig)

Source

Yeast

Expression Region

1-1149

Target Protein Sequence

MACPWNFLWK LKSSRYDLTE EKDINNNVGK ASHLYSPEIQ DDPKYCSPGK HQNGSSQSLT GTAKKVPESQ SKPHKPSPTC SQHMKIKNWG NGMILQDTLH TKAKTNFTCK PKSCLGSVMN PRSMTRGPRD TPIPPDELLP QAIEFVNQYY DSFKEAKIEE YLARVETVTK EIETTGTYQL TGDELIFATK LAWRNAPRCI GRIQWSNLQV FDARSCHTAQ EMFEHICRHV RYSTNNGNIR SAITVFPQRT DGKHDFRVWN AQLIRYAGYQ MPDGTIQGDP ANLEFTQLCI DLGWKPRYGR FDVLPLILQA DGRDPELFEI PPDLVLEVPM EHPKYEWFQD LGLKWYALPA VANMLLEVGG LEFPACPFNG WYMGTEIGVR DFCDAQRYNI LEEVGRRMGL ETHTLASLWK DRAVTEINVA VLHSFQKQNV TIMDHHSAAE SFMKHMQNEY RARGGCPADW IWLVPPISGS ITPVFHQEML NYILSPFYYY QVEAWKTHVW QDETRRPKRR EIPFRVLAKA TLFASLLMRK MMASRVRATI LFATETGKSE ALAQDLGALF SCAFNPKVLC MDQYQLSSLE EEKLLLVVTS TFGNGDCPGN GETLKKSLFV LKKLTNTFRY AVFGLGSSMY PRFCAFAHDI DIKLSQLGAS QLTPVGEGDE LSGQEDAFCT WAVQTFQAAC AAFDVRGRHH ITIPKRYTSS VTWEPYHYRL VQDSQPLDLN KALSRMHATD VFTMRLKSQK NLQSPKSSRT TLLMELSCDD SRSLAYLPGE HLGVFPCNQP ALVQGILECV VDNPGPHHTV CLEVLDDSGS YWAKDKRLPP CSLSQALTYF LDITTPPTQL QLQKLARLAT EQAERLRLES LSQPSEYNKW KFTNSPTFLE VLEEFPSLRV PAAFLLSQLP ILKPRYYSIS SSLDHTPAEV HLTVAVVTYR TRDGRGPLHH GVCSTWFSGL KPQDPVPCLV RSVNSFQLPK DPSQPCILIG PGTGIAPFRS FWQQRLHNLK HTGLQGGRMT LLFGCRHPEE DHIYKEEMQE MVQKGVLHEV HTAYSRLPGK PKAYVQDILR QQLAREVLRV LHEEPGHLYV CGNVLMAQDV ACTLKQLLAA KLNLNEEQVE DYFFQLKSQK RYHEDIFGAV FPHGVKKDRA ERPPGDDKL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.

Gene References into Functions

The expression of iNOS participates in the pathogenesis of cochlear damage caused by acoustic trauma. PMID:22687355
Our data demonstrate that both iNOS and nNOS represent sources for nitric oxide overproduction in ileal myenteric plexus during ischemia and reperfusion PMID:23279126
Salvia miltiorrhiza injection had no effect on the expression of nNOS and eNOS, but could inhibit iNOS in choclea. PMID:21845886
iNOS and AChE expression increases in spiral ganglia treated with streptomycin. Salvia miltiorrhiza injection reduces ototoxicity by reducing the levels of iNOS and AChE. PMID:21189568
The auditory brainstem response threshold increases and the expression of iNOS strengthens in streptomycin ototoxicity. PMID:21166178