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Recombinant Epstein-Barr virus Major DNA-binding protein (DBP), partial

Recombinant Epstein-Barr virus Major DNA-binding protein (DBP), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

DBP

Uniprot NO.

P03227

Species

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Source

Yeast

Target Protein Sequence

MQGAQTSEDN LGSQSQPGPC GYIYFYPLAT YPLREVATLG TGYAGHRCLT VPLLCGITVE PGFSINVKAL HRRPDPNCGL LRATSYHRDI YVFHNAHMVP PIFEGPGLEA LCGETREVFG YDAYSALPRE SSKPGDFFPE GLDPSAYLGA VAITEAFKER LYSGNLVAIP SLKQEVAVGQ SASVRVPLYD KEVFPEGVPQ LRQFYNSDLS RCMHEALYTG LAQALRVRRV GKLVELLEKQ SLQDQAKVAK VAPLKEFPAS TISHPDSGAL MIVDSAACEL AVSYAPAMLE ASHETPASLN YDSWPLFADC EGPEARVAAL HRYNASLAPH VSTQIFATNS VLYVSGVSKS TGQGKESLFN SFYMTHGLGT LQEGTWDPCR RPCFSGWGGP DVTGTNGPGN YAVEHLVYAA SFSPNLLARY AYYLQFCQGQ KSSLTPVPET GSYVAGAAAS PMCSLCEGRA PAVCLNTLFF RLRDRFPPVM STQRRDPYVI SGASGSYNET DFLGNFLNFI DKEDDGQRPD DEPRYTYWQL NQNLLERLSR LGIDAEGKLE KEPHGPRDFV KMFKDVDAAV DAEVVQFMNS MAKNNITYKD LVKSCYHVMQ YSCNPFAQPA CPIFTQLFYR SLLTILQDIS LPICMCYEND NPGLGQSPPE WLKGHYQTLC TNFRSLAIDK GVLTAKEAKV VHGEPTCDLP DLDAALQGRV YGRRLPVRMS KVLMLCPRNI KIKNRVVFTG ENAALQNSFI KSTTRRENYI INGPYMKFLN TYHKTLFPDT KLSSLYLWHN FSRRRSVPVP SGASAEEYSD LALFVDGGSR AHEESNVIDV VPGNLVTYAK QRLNNAILKA CGQTQFYISL IQGLVPRTQS VPARDYPHVL GTRAVESAAA YAEATSSLTA TTVVCAATDC LSQVCKARPV VTLPVTINKY TGVNGNNQIF QAGNLGYFMG RGVDRNLLQA PGAGLRKQAG GSSMRKKFVF ATPTLGLTVK RRTQAATTYE IENIRAGLEA IISQKQEEDC VFDVVCNLVD AMGEACASLT RDDAEYLLGR FSVLADSVLE TLATIASSGI EWTAEAARDF LEGVWGGPGA AQDNFISVAE PVSTASQASA GLLLGGGGQG SGGRRKRRLA TVLPGLEV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.

Gene References into Functions

The structural features of a C-terminal deletion construct of the Epstein-Barr virus single-stranded DNA-binding protein, Balf2, were reported. PMID:18068378
BMRF1 protein is a multifunctional protein that cannot only act as a DNA polymerase processivity factor but also enhances BALF2 promoter transcription as a coactivator for the BZLF1 protein PMID:19491105

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Subcellular Location

Virion tegument. Host nucleus.

Protein Families

Herpesviridae major DNA-binding protein family

Database Links

KEGG: vg:3783678

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