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Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2 (EBNA2), partial

Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2 (EBNA2), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

EBNA2

Purity

>85% (SDS-PAGE)

Target Names

EBNA2

Uniprot NO.

Q69022

Species

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)

Source

E.coli

Expression Region

247-454aa

Target Protein Sequence

MPTYYLALHG GQSYNLIVDT DMSGNPSLSV IPTNPYQEQL SNNPLIQLQI VVGENTGAPA PPQPPPPPPP PPPPERRDAW TQEPLPLDMN PLGSDASQGP LASSIRMLCM AQYLLRNARG QQGLLRPLGP QTRSQVTLER QPVHNPRQEA PIILLQSPAP PRFTPVPMVA LGHTLQPTPP PRPTLPQPRI PLIIPPRHTN QPATTPPTAP QRLTLGHQLS LPPHPPPHQS TPHCSSDSTG LPPPPTSYSI PSMTLSPEPL PPPAAPAHPL PGVIYDQQAL PPTPGPPWWP PVRDPTPTTQ TPPTNTKQGP DQGQGRGRWR GRGRSKGRGR MHKLPEPRRP GPDTSSPSMP QLSPVVSLHQ GQGPENSPTP GPSTAGPVCR VTPSATPDIS PIHEPESSDS EEPPFLFPSD WYPPTLEPAE LDESWEGIFE TTESHSSDEE NVGGPSKRPR TSTQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells.

Subcellular Location

Host nucleus matrix.

Protein Families

Herpesviridae EBNA2 family

Database Links

KEGG: vg:5176198

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