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Recombinant Eospalax baileyi Hypoxia-inducible factor 1-alpha (HIF1A), partial

Recombinant Eospalax baileyi Hypoxia-inducible factor 1-alpha (HIF1A), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

HIF1A

Purity

>85% (SDS-PAGE)

Target Names

HIF1A

Uniprot NO.

Q309Z6

Species

Eospalax fontanierii baileyi (Plateau zokor) (Eospalax baileyi)

Source

Yeast

Expression Region

1-819

Target Protein Sequence

MEGAAGGEEK KNRMSSERRK EKSRDAARSR RSKESEVFYE LAHQLPLPHN VSSHLDKASV MRLTISYLRV RKLLDAGDLD IEDDMKAQMN CFYLKALDGF VMVLTDDGDM IYISDNVNKY MGLTQFELTG HSVFDFTHPC DHEEMREMLT HRNGPIKKGK EQNTQRSFFL RMKCTLTSRG RTMNIKSATW KVLHCTGHIH VYDTNSNQPQ CGYKKPPMTC LVLICEPIPH PSNIEIPLDS KTFLSRHSLD MKFSYCDERI TELMGYEPEE LLGRSIYEYY HALDSDHLTK THHDMFTKGQ VTTGQYRMLA KRGGYVWVET QATVIYNTKN SQPQCIVCVN YVVSGIIQHD LIFSLQQTEC VLKPVESSDM KMTQLFTKVE SEDTSCLFDK LKKEPDALTL LAPAAGDTII SLDFGSDDTE TEDQQLEDVP LYNDVMFPSS DDKLTSINLA MSPLPASETP KPLRSNADPA LNQEVALKLE PNAESLELSF TMPQIQDQPA SPSDGSTRQS SPEPNSPSEY CFDVDSDMVN VFKLELVEKL FAEDTEAKNP FSTQDTDLDL EMLAPYIPMD DDFQLRSFDQ LSPLESSSPN PPSVSTAFQQ TQLQEPTITT TTTEELKTVT KDSTEDIKIL ITSPSSTHTP KETTTATTSS PYSGTQSRTA SPNRAGQGVI EQTEKSHPRS PNVLSVTLSQ RNTVPEEELN PKIIALQNAQ RKRKMEHDGS LFQAAGIGTL LQQPDDRAPA TSLSWKRVKG CKSSGQNGME QKTIILIPSD LACRLLGQSM DGSGLPQLTS YDCEVNAPIQ GSRNLLQGEE LLRALDQVN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Subcellular Location

Cytoplasm. Nucleus. Nucleus speckle.

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